Disclosures of conflicts of interest: K.J.F. Member of Radiology editorial board; grants from GE, Siemens, Bayer; payment for lectures from Bayer Liver Forum; participation on founding board of Quantix Bio; ACR LI-RADS steering committee member. V.C. Consulting fees from Bayer. M.R. Payment for lectures from GE Healthcare, Ipsen, Canon-Toshiba, Alexion Pharmaceuticals, Guerbet, Sirtex. V.V. No relevant relationships. A.K. No relevant relationships. J.M.L. Grant from Samsung Medison, Siemens Healthineers, Philips Healthcare, GE Healthcare, Bayer, Guerbet, CMS, Canon Healthcare, Dongkuk Pharma; payment for lectures from Samsung Medison, GE Healthcare, Philips Healthcare, Starmed. U.M. No relevant relationships. B.S. No relevant relationships. H.J. Supported by the National Natural Science Foundation of China (81971571) and the Science and Technology Department of Sichuan Province (2021YFS0021). C.B.S. Research grants from ACR, Bayer, GE, Gilead, Pfizer, Philips, Siemens; Research grants from federal sources: NIH, DOD; Lab service agreements from Enanta, Gilead, ICON, Intercept, Nusirt, Shire, Synageva, Takeda; royalties or licenses from Medscape, Wolters Kluwer; consulting fees from Blade, Boehringer, Epigenomics, AMRA, BMS, Exact Sciences, IBM-Watson, Pfizer; honoraria from Educational Symposia; honoraria for visiting professor and /or grand rounds lectures from universities; member, Board of Directors of Society of Abdominal Radiology; stock options in Livivos; unpaid advisor for QuantixBio. M.R.B. Member of Radiology editorial board; grants from Carmot Therapeutics, Corcept Therapeutics, Diabetes and Endocrinology Consultants, Madrigal Pharmaceuticals, Metacrine, NGM Biopharmaceuticals, Polarean Imaging, ProSciento, Siemens Healthineers; consulting fees from ICON, MedPace.