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. 2024 Feb;17(1):104-120.
doi: 10.1007/s12265-023-10382-w. Epub 2023 Apr 4.

FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure

Tan Xu #  1 , Jiaxing Wang #  1 , Xiaoxiao Liu #  2 , Rui Xiang  3 , Houhua Li  4 , Shiqiang Wang  2 , Jichun Yang  5 , Ming Xu  6   7
Affiliations

FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure

Tan Xu et al. J Cardiovasc Transl Res. 2024 Feb.

Abstract

Mitochondrial protein sequence similarity 3 gene family member A (FAM3A) plays important roles in the electron transfer chain, while its functions in the heart are still unknown. This study aims to explore the roles and mechanisms of FAM3A after myocardial infarction (MI). FAM3A-deficient (Fam3a-/-) mice were implemented with MI injury and showed lower survival rates at 4 weeks as well as decreased cardiac systolic function. Isolated cardiomyocytes of Fam3a-/- mice showed reduced basal, ATP-linked respiration and respiratory reserve compared to that of wild-type mice. Transmission electron microscopy studies showed Fam3a-/- mice had a larger size and elevated density of mitochondria. FAM3A deficiency also induced elevated mitochondrial Ca2+, higher opening level of mPTP, lower mitochondrial membrane potential and elevated apoptotic rates. Further analyses demonstrated that mitochondrial dynamics protein Opa1 contributed to the effects of FAM3A in cardiomyocytes. Our study discloses the important roles of mitochondrial protein FAM3A in the heart.

Keywords: FAM3A; Heart failure; Mitochondrial dysfunction; Myocardial infarction; Opa1.

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