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. 2023 Sep;17(3):1105-1111.
doi: 10.1007/s12079-023-00742-1. Epub 2023 Apr 4.

An assembly of TROP2-mediated signaling events

Shubham Sukerndeo Upadhyay  1 , Rex Devasahayam Arokia Balaya  2 , Sakshi Sanjay Parate  1 , Shobha Dagamajalu  1 , T S Keshava Prasad  1 , Rohan Shetty  3 , Rajesh Raju  4   5
Affiliations

An assembly of TROP2-mediated signaling events

Shubham Sukerndeo Upadhyay et al. J Cell Commun Signal. 2023 Sep.

Abstract

Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein mainly involved in embryo development. The aberrant expression of TROP2 is observed in numerous cancers, including triple-negative breast cancer, gastric, colorectal, pancreatic, squamous cell carcinoma of the oral cavity, and prostate cancers. The main signaling pathways mediated by TROP2 are calcium signaling, PI3K/AKT, JAK/STAT, MAPKs, and β-catenin signaling. However, collective information about the TROP2-mediated signaling pathway is not available for visualization or analysis. In this study, we constructed a TROP2 signaling map with respect to its role in different cancers. The data curation was done manually by following the NetPath annotation criteria. The described map consists of different molecular events, including 8 activation/inhibition, 16 enzyme catalysis, 19 gene regulations, 12 molecular associations, 39 induced-protein expressions, and 2 protein translocation. The data of the TROP2 pathway map is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5300 ). Development of TROP2 signaling pathway map.

Keywords: Cancer; Protein–protein interactions; Signalling pathway; Triple-negative breast cancer; WikiPathways.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

None
Development of TROP2 signaling pathway map
Fig. 1
Fig. 1
Schematic representation of TROP2 mediated signaling mechanism in different types of cancers
See this image and copyright information in PMC

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