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. 2023 Jul;27(7):3321-3330.
doi: 10.1007/s00784-023-05012-3. Epub 2023 Apr 4.

Effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis: a scoping review

Giusy Rita Maria La Rosa  1 , Antonia Marcianò  2 , Carlotta Ylenia Priolo  3 , Matteo Peditto  4 , Eugenio Pedullà #  3 , Alberto Bianchi #  3
Affiliations

Effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis: a scoping review

Giusy Rita Maria La Rosa et al. Clin Oral Investig. 2023 Jul.

Abstract

Objectives: The aim of this scoping review was to determine the effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis.

Materials and methods: Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. A literature search was conducted in the PubMed and Scopus databases to identify all clinical studies on the application of platelet-rich fibrin in the control of pain caused by alveolar osteitis. Data were extracted independently by two reviewers and qualitatively described.

Results: The initial search returned 81 articles, with 49 identified after duplicates removal; of these, 8 were selected according to the inclusion criteria. Three of the eight studies were randomized controlled clinical trials, and four were non-randomized clinical studies, two of which were controlled. One study was case series. In all of these studies, pain control was evaluated using the visual analog scale. Overall, the use of platelet-rich fibrin resulted effective in the control of pain determined by alveolar osteitis.

Conclusions: Within the limits of this scoping review, the application of platelet-rich fibrin in the post-extra-extraction alveolus reduced the pain associated with alveolar osteitis in almost all the included studies. Nevertheless, high-quality randomized trials with adequate sample size are warranted to draw firm conclusions.

Clinical relevance: Pain associated with alveolar osteitis causes discomfort to the patient and is challenging to be treated. Use of platelet-rich fibrin could be a promising clinical strategy for pain control in alveolar osteitis if its effectiveness will be confirmed by further high-quality studies.

Keywords: Alveolar osteitis; Dry socket; Pain control; Platelet-rich fibrin; Scoping review.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of the review process
See this image and copyright information in PMC

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