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. 2023 Jul;27(7):3839-3853.
doi: 10.1007/s00784-023-05002-5. Epub 2023 Apr 4.

Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model

Rafaela Nanami Handa Inada  1 , Marcela Borsatto Queiroz  1 , Camila Soares Lopes  1 , Evelin Carine Alves Silva  1 , Fernanda Ferrari Esteves Torres  1 , Guilherme Ferreira da Silva  2 , Juliane Maria Guerreiro-Tanomaru  1 , Paulo Sérgio Cerri  3 , Mário Tanomaru-Filho  4
Affiliations

Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model

Rafaela Nanami Handa Inada et al. Clin Oral Investig. 2023 Jul.

Abstract

Objectives: This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM).

Materials and methods: Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey's tests (p < 0.05).

Results: IRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (p < 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (p < 0.05).

Conclusions: BIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids.

Clinical relevance: BIOC-R and MTAHP have adequate biological properties. BIOC-R demonstrated lower porosity and presence of voids, which may represent better sealing for its clinical applications.

Keywords: Biocompatibility; Calcium silicate; Root repair materials; X-ray microtomography.

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References

    1. Guimarães BM, Prati C, Duarte MAH et al (2018) Physicochemical properties of calcium silicate-based formulations MTA Repair HP and MTA Vitalcem. J Appl Oral Sci 26:e2017115. https://doi.org/10.1590/1678-7757-2017-0115 - DOI - PubMed - PMC
    1. Queiroz MB, Inada RNH, Jampani JLA et al (2022) Biocompatibility and bioactive potential of an experimental tricalcium silicate-based cement in comparison with Bio-C repair and MTA Repair HP materials. Int Endod J 56:259–277. https://doi.org/10.1111/iej.13863 - DOI - PubMed
    1. Benetti F, de Queiroz ÍO A, Cosme-Silva L et al (2019) Cytotoxicity, biocompatibility and biomineralization of a new ready-for-use bioceramic repair material. Braz Dent J 30:325–332. https://doi.org/10.1590/0103-6440201902457 - DOI - PubMed
    1. Rodríguez-Lozano FJ, Lozano A, López-García S et al (2022) Biomineralization potential and biological properties of a new tantalum oxide (Ta2O5)–containing calcium silicate cement. Clin Oral Investig 26:1427–1441. https://doi.org/10.1007/s00784-021-04117-x - DOI - PubMed
    1. Torres FFE, Pinto JC, Figueira GO et al (2021) A micro-computed tomographic study using a novel test model to assess the filling ability and volumetric changes of bioceramic root repair materials. Restor Dent Endod 46:1–8. https://doi.org/10.5395/rde.2021.46.e2 - DOI

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