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. 2023 Oct 3;228(7):851-856.
doi: 10.1093/infdis/jiad094.

Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort

Asmaa El-Heneidy  1 , Keith Grimwood  1   2 , Stephen B Lambert  3   4 , Robert S Ware  1
Affiliations

Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort

Asmaa El-Heneidy et al. J Infect Dis. .

Abstract

Background: Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor.

Methods: In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-one paired swabs collected within 10-days of RotaTeq vaccination from 140 infants were tested for 10 enteric viruses and RotaTeq strains.

Results: Collectively, both ribonucleic acid and deoxyribonucleic acid viruses were negatively associated with RotaTeq shedding (adjusted odds ratio = 0.29, 95% confidence interval = 0.14-0.58 and adjusted odds ratio = 0.30, 95% confidence interval = 0.11-0.78, respectively).

Conclusions: Enteric viruses may interfere with RotaTeq replication in the gut and thus RotaTeq stool shedding.

Keywords: ORChID; RotaTeq; enteric viruses; interference; oral vaccine.

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Conflict of interest statement

Potential conflicts of interest . All authors: No reported conflicts of interest.

Figures

Figure 1.
Figure 1.
Submission of stool swabs, and positive RotaTeq detections in the Observational Research in Childhood Infectious Diseases (ORChID) study.
See this image and copyright information in PMC

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