Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 May;33(5):331-332.
doi: 10.1038/s41422-023-00803-5.

Positively charged patches: tonic for CAR fitness

Affiliations
Comment

Positively charged patches: tonic for CAR fitness

Meraj H Khan et al. Cell Res. 2023 May.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Schematic illustration depicting CAR design and the effect of PCPs on the fitness of CARs.
a The three main domains of a CAR, antigen-binding domain, transmembrane domain and intracellular signaling domain. b The effect of low and high PCPs on tonic signaling, CAR persistence and exhaustion. c An optimal PCPs for spontaneous weak tonic signaling and stable CAR functions. Created with BioRender.com

Comment on

References

    1. Rafiq S, Hackett CS, Brentjens RJ. Nat. Rev. Clin. Oncol. 2020;17:147–167. doi: 10.1038/s41571-019-0297-y. - DOI - PMC - PubMed
    1. Schuster SJ, et al. N. Engl. J. Med. 2019;380:45–56. doi: 10.1056/NEJMoa1804980. - DOI - PubMed
    1. Majzner RG, Mackall CL. Nat. Med. 2019;25:1341–1355. doi: 10.1038/s41591-019-0564-6. - DOI - PubMed
    1. Myers DR, Zikherman J, Roose JP. Trends Immunol. 2017;38:844–857. doi: 10.1016/j.it.2017.06.010. - DOI - PMC - PubMed
    1. Long AH, et al. Nat. Med. 2015;21:581–590. doi: 10.1038/nm.3838. - DOI - PMC - PubMed

MeSH terms