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. 2023;57(1):1-6.
doi: 10.1134/S0026893323010028. Epub 2023 Mar 30.

Interleukin-11 in Pathologies of the Nervous System

M I Airapetov  1   2 , S O Eresko  2   3 , P D Ignatova  1 , A A Lebedev  2 , E R Bychkov  2 , P D Shabanov  2   4
Affiliations

Interleukin-11 in Pathologies of the Nervous System

M I Airapetov et al. Mol Biol. 2023.

Abstract

The study of the role of cytokines in various pathological conditions of the body is a topical area in modern biomedicine. Understanding the physiological roles played by cytokines will aid in finding applications for them as pharmacological agents in clinical practice. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been increased interest in this cytokine in recent years. IL-11 has been shown to correct inflammatory pathways in the epithelial tissues of the respiratory system, where the main events occur during SARS-CoV-2 infection. Further research in this direction will probably support the use of this cytokine in clinical practice. The cytokine plays a significant role in the central nervous system; local expression by nerve cells has been shown. Studies show the involvement of IL-11 in the mechanisms of development of a number of pathologies of the nervous system, and therefore it seems relevant to generalize and analyze the experimental data obtained in this direction. This review summarizes information that shows the involvement of IL-11 in the mechanisms of development of brain pathologies. In the near future this cytokine will likely find clinical application for the correction of mechanisms that are involved in the formation of pathological conditions of the nervous system.

Keywords: IL-11; IL-6 family; brain; gp130; neurodegeneration; neuroinflammation.

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Conflict of interest statement

The authors declare no conflicts of interest. This article does not contain any studies involving humans or animals as research subjects.

Figures

Fig. 1.
Fig. 1.
Structure of IL-11. The binding sites of the cytokine with the receptor complex are marked. The figure was constructed according to the data from Barton V. et al. [17].
Fig. 2.
Fig. 2.
Intracellular IL-11 signal transduction pathways.
See this image and copyright information in PMC

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