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Randomized Controlled Trial
. 2023 Jul 15;129(14):2135-2143.
doi: 10.1002/cncr.34779. Epub 2023 Apr 5.

Effects of an educational physical activity intervention in young women with newly diagnosed breast cancer: Findings from the Young and Strong Study

Jennifer A Ligibel  1   2 , Yue Zheng  1 , William T Barry  1 , Tal Sella  3 , Kathryn J Ruddy  4 , Mary L Greaney  5 , Shoshana M Rosenberg  6 , Karen M Emmons  7 , Ann H Partridge  1   2
Affiliations
Free article
Randomized Controlled Trial

Effects of an educational physical activity intervention in young women with newly diagnosed breast cancer: Findings from the Young and Strong Study

Jennifer A Ligibel et al. Cancer. .
Free article

Abstract

Background: Obesity and inactivity are poor prognostic factors in breast cancer, but less is known regarding physical activity (PA) and weight patterns in young breast cancer survivors.

Methods: The Young and Strong Study was a cluster-randomized trial evaluating education and support interventions for young women (age <45 years) with newly diagnosed breast cancer. Sites were randomized 1:1 to a Young Women's Intervention (YWI) or a contact-time control physical activity intervention (PAI). Changes in PA and weight were compared between groups using general estimating equations to evaluate clustered binary and Gaussian data.

Results: A total of 467 patients enrolled between July 2012 and December 2013 across 54 sites. Median age at diagnosis was 40 years (range, 22-45). At baseline, median body mass index (BMI) was 25.4 kg/m2 (range, 16.1-61.1), and participants reported a median of 0 minutes (range, 0-2190) of moderate/vigorous PA/week. PA increased significantly over time in both groups (p < .001), with no difference between groups at any time point. BMI increased modestly but significantly (p < .001) over time in both groups. Provider attention to PA was observed in 74% of participants on PAI and 61% on YWI (p = .145) and correlated with PA at 12 months (median 100 min/week of PA in participants with provider attention to PA vs. 60 min/week in those without, p = .016).

Conclusions: In a cohort of young women with breast cancer, rates of obesity and inactivity were high. PA and BMI increased over time and were not impacted by an educational PA intervention. Findings provide important information for developing lifestyle interventions for young breast cancer survivors.

Keywords: Young and Strong; breast cancer; obesity; physical activity; young women.

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References

REFERENCES

    1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7-33. doi:10.3322/caac.21708
    1. Rosenberg SM, Newman LA, Partridge AH. Breast cancer in young women: rare disease or public health problem? JAMA Oncol. 2015;1(7):877-878. doi:10.1001/jamaoncol.2015.2112
    1. Partridge AH, Hughes ME, Warner ET, et al. Subtype-dependent relationship between young age at diagnosis and breast cancer survival. J Clin Oncol. 2016;34(27):3308-3314. doi:10.1200/jco.2015.65.8013
    1. Thomas A, Rhoads A, Pinkerton E, et al. Incidence and survival among young women with stage I-III breast cancer: SEER 2000-2015. JNCI Cancer Spectr. 2019;3. doi:10.1093/jncics/pkz040
    1. Daling JR, Malone KE, Doody DR, Johnson LG, Gralow JR, Porter PL. Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma. Cancer. 2001;92(4):720-729. doi:10.1002/1097-0142(20010815)92:4<720::aid-cncr1375>3.0.co;2-t

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