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. 2023 May 3;78(5):1160-1167.
doi: 10.1093/jac/dkac443.

Resistance is common in paediatric patients failing ART in South Africa

Gillian M Hunt  1   2 , Mukhlid Yousif  1   2 , Leon Levin  3 , Johanna Ledwaba  1 , Kim Steegen  4   5 , Tendesayi Kufa  1   6 , Hloniphile Zwane  1 , Monalisa Kalimashe  1 , Vibha Kana  1 , Getahun Aynalem  7 , Jaclyn Perlman  7 , Kassahun Ayalew  7 , Gurpreet Kindra  7 , Karidia Diallo  7 , Sergio Carmona  4   5 , Gayle Sherman  1   5   8 , Elliot J Raizes  9
Affiliations

Resistance is common in paediatric patients failing ART in South Africa

Gillian M Hunt et al. J Antimicrob Chemother. .

Abstract

Background: Minimal data exist on HIV drug resistance patterns and prevalence among paediatric patients failing ART in resource-limited settings. We assessed levels of HIV drug resistance in children with virological failure.

Methods: This cross-sectional study, performed from March 2017 to March 2019 in South Africa, enrolled HIV-positive children aged ≤19 years, receiving ART through public health facilities with recent evidence suggestive of virological failure (at least one viral load ≥1000 copies/mL), across 45 randomly selected high-volume clinics from all nine provinces. Resistance genotyping was performed using next-generation sequencing technologies. Descriptive analysis taking into account survey design was used to determine outcomes.

Results: Among 899 participants enrolled, the adjusted proportion of HIV drug resistance among children with virological failure was 87.5% (95% CI 83.0%-90.9%). Resistance to NNRTIs was detected in 77.4% (95% CI 72.5%-81.7%) of participants, and resistance to NRTIs in 69.5% (95% CI 62.9%-75.4%) of participants. Overall, resistance to PIs was detected in 7.7% (95% CI 4.4%-13.0%) of children.

Conclusions: HIV drug resistance was highly prevalent in paediatric patients failing ART in South Africa, with 9 in 10 patients harbouring resistance to NNRTIs and/or NRTIs. PI-based regimens are predicted to be highly efficacious in achieving virological suppression amongst patients failing NNRTI-based regimens. Scaling up resistance testing amongst patients would facilitate access to second- and third-line regimens in South Africa.

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Figures

Figure 1.
Figure 1.
Final enrolment study flow chart.
Figure 2.
Figure 2.
Unadjusted predicted resistance profiles amongst paediatric participants failing ART, categorized according to current regimen in use (n = 805). PI, PI-based regimen, n = 369 participants; NNRTI, NNRTI-based regimen, n = 384 participants; NRTI, NRTI-based regimen, n = 52 participants.
Figure 3.
Figure 3.
Unadjusted patterns of HIV drug resistance mutations in paediatric participants with virological failure, n = 809. Note: only mutations present at ≥1.0% are depicted in this figure.
See this image and copyright information in PMC

References

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