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Review
. 2023 May;82(4):298-306.
doi: 10.1007/s00393-023-01343-4. Epub 2023 Apr 5.

[Principles of allergy diagnostics]

[Article in German]
Ulrich Seidl  1 , Guido Heine  2
Affiliations
Review

[Principles of allergy diagnostics]

[Article in German]
Ulrich Seidl et al. Z Rheumatol. 2023 May.

Abstract
in English, German

Background: Allergies are frequent and approximately 30% of the general population in Germany are affected. The specific sensitization against an allergen is asymptomatic. On renewed allergen contact the symptoms are indicative of the underlying pathomechanism. A variety of different test procedures are available to identify allergic reactions.

Objective and aim: In this review article the typical clinical symptoms of allergic reactions are assigned to mechanisms and possible test methods are presented and discussed. Current developments in recombinant serum diagnostics and cellular testing methods are presented.

Zusammenfassung: HINTERGRUND: Allergien sind häufig, fast 30 % der deutschen Bevölkerung sind betroffen. Die spezifische Sensibilisierung gegen ein Allergen verläuft asymptomatisch. Bei erneutem Allergenkontakt weisen die Symptome auf den Pathomechanismus hin. Es stehen zahlreiche unterschiedliche Testverfahren für allergische Reaktionen zur Verfügung.

Fragestellung und ziel: In dieser Übersichtsarbeit werden die typischen klinischen Symptome allergischer Reaktionen den Mechanismen zugeordnet und mögliche Testmethoden vorgestellt und diskutiert. Aktuelle Entwicklungen der rekombinanten Serumdiagnostik und zellulären Testverfahren werden vorgestellt.

Keywords: Epicutaneous testing; Exposure testing; Intracutaneous testing; Type I allergy; Type IV allergy.

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References

Literatur

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