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. 2023 Mar 31;80(1):36-42.
doi: 10.31053/1853.0605.v80.n1.36817.

[Pathophysiology and diagnostic and therapeutic algorithm of MINOCA]

[Article in Spanish]
Affiliations

[Pathophysiology and diagnostic and therapeutic algorithm of MINOCA]

[Article in Spanish]
Juan Pablo Ricarte-Bratti et al. Rev Fac Cien Med Univ Nac Cordoba. .

Abstract

MINOCA is a syndrome that encompasses several pathologies and occurs in the clinical context of an Acute Coronary Syndrome. Its incidence varies according to the population studied, the diagnostic methods used and whether they have included Myocarditis and Takotsubo Syndrome, which were recently excluded from the definition of MINOCA. For this reason, we consider that the novelty of this publication is the non-inclusion of these two pathologies and, therefore, the objective of this review is to update this syndrome concisely. The management of the three types of MINOCA is also addressed, whose diagnosis is mainly based in using specific complementary images, since coronary angiography has its limitations. Treatment will generally be pharmacological according to the pathophysiological mechanism involved.

MINOCA es un síndrome que abarca varias patologías y que ocurre en el contexto clínico de un Síndrome Coronario Agudo. Su incidencia varía de acuerdo con la población estudiada, métodos de diagnósticos utilizados y si han incluido a la Miocarditis y Síndrome de Takotsubo, los cuáles, fueron excluidos recientemente de la definición de MINOCA. Por esta razón, consideramos que la novedad de esta publicación es la no inclusión de estas dos patologías y, por lo tanto, el objetivo de la presente revisión es actualizar este síndrome de forma concisa. También se aborda el manejo de los tres tipos de MINOCA, cuyo diagnóstico se basa fundamentalmente en la utilización de imágenes complementarias específicas, ya que la coronariografia tiene sus limitaciones. El tratamiento será en general farmacológico de acuerdo con el mecanismo fisiopatológico involucrado.

Keywords: MINOCA; myocardial infarction; acute coronary syndrome.

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Conflict of interest statement

Conflicto de interés:

Ninguno.

Figures

Figura N °1
Figura N °1. Tipos de Minoca según la fisiopatología.
Figura N ° 2
Figura N ° 2. Algoritmo propuesto de manejo del MINOCA.
Figura N °3
Figura N °3. Resumen del tratamiento del MINOCA.

References

    1. Singh T, Chapman AR, Dweck MR, Mills NL, Newby DE. MINOCA: a heterogenous group of conditions associated with myocardial damage. Heart. 2021 Sep;107(18):1458-1464. doi: 10.1136/heartjnl-2020-318269. - PubMed
    2. Singh T, Chapman AR, Dweck MR, Mills NL, Newby DE. MINOCA: a heterogenous group of conditions associated with myocardial damage. Heart. 2021 Sep;107(18):1458–1464. doi: 10.1136/heartjnl-2020-318269. - DOI - PubMed
    1. Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF. Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries. Circulation. 2015 Mar 10;131(10):861-70. doi: 10.1161/CIRCULATIONAHA.114.011201. - PubMed
    2. Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF. Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries. Circulation. 2015 Mar 10;131(10):861–70. doi: 10.1161/CIRCULATIONAHA.114.011201. - DOI - PubMed
    1. Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, De Caterina R, Zimarino M, Roffi M, Kjeldsen K, Atar D, Kaski JC, Sechtem U, Tornvall P; WG on Cardiovascular Pharmacotherapy. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J. 2017 Jan 14;38(3):143-153. doi: 10.1093/eurheartj/ehw149. - PubMed
    2. Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, De Caterina R, Zimarino M, Roffi M, Kjeldsen K, Atar D, Kaski JC, Sechtem U, Tornvall P, WG on Cardiovascular Pharmacotherapy ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J. 2017 Jan 14;38(3):143–153. doi: 10.1093/eurheartj/ehw149. - DOI - PubMed
    1. Barr PR, Harrison W, Smyth D, Flynn C, Lee M, Kerr AJ. Myocardial Infarction Without Obstructive Coronary Artery Disease is Not a Benign Condition (ANZACS-QI 10). Heart Lung Circ. 2018 Feb;27(2):165-174. doi: 10.1016/j.hlc.2017.02.023. - PubMed
    2. Barr PR, Harrison W, Smyth D, Flynn C, Lee M, Kerr AJ. Myocardial Infarction Without Obstructive Coronary Artery Disease is Not a Benign Condition (ANZACS-QI 10) Heart Lung Circ. 2018 Feb;27(2):165–174. doi: 10.1016/j.hlc.2017.02.023. - DOI - PubMed
    1. Diver DJ, Bier JD, Ferreira PE, Sharaf BL, McCabe C, Thompson B, Chaitman B, Williams DO, Braunwald E. Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA Trial). Am J Cardiol. 1994 Sep 15;74(6):531-7. doi: 10.1016/0002-9149(94)90739-0. - PubMed
    2. Diver DJ, Bier JD, Ferreira PE, Sharaf BL, McCabe C, Thompson B, Chaitman B, Williams DO, Braunwald E. Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA Trial) Am J Cardiol. 1994 Sep 15;74(6):531–7. doi: 10.1016/0002-9149(94)90739-0. - DOI - PubMed

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