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Comment
. 2023 Apr 4;35(4):551-553.
doi: 10.1016/j.cmet.2023.03.009.

Senescence of bone marrow fat cells: A new clue for glucocorticoid-induced bone deterioration

Liping Tong  1 , Di Chen  2
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Comment

Senescence of bone marrow fat cells: A new clue for glucocorticoid-induced bone deterioration

Liping Tong et al. Cell Metab. .

Abstract

Glucocorticoid (GC)-induced osteoporosis is the most common secondary cause of osteoporosis, resulting in fractures and significant morbidity. In this issue of Cell Metabolism, Liu et al. reveal that in response to GCs, bone marrow adipocytes (BMAds) undergo rapid cellular senescence, triggering secondary senescence in bone marrow and causing bone deterioration.

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Declaration of interests The authors declare no competing interests.

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