Intravenous lidocaine overdosage in a child
- PMID: 3701908
- DOI: 10.3109/15563658608990445
Intravenous lidocaine overdosage in a child
Abstract
A six-year-old child inadvertently received an IV solution containing lidocaine HCl. An estimated total dose of 1.2 gm. was administered over approximately an hour. The child had asystole and grand mal seizures associated with lidocaine serum concentration of 19.2 mcg/ml. The pharmacokinetics of lidocaine overdose and treatment are discussed.
Similar articles
-
Accidental lidocaine overdosage in an infant.J Toxicol Clin Toxicol. 1990;28(1):101-6. doi: 10.3109/15563659008993480. J Toxicol Clin Toxicol. 1990. PMID: 2381015
-
Lidocaine toxicity.Ann Emerg Med. 1980 Dec;9(12):627-9. doi: 10.1016/s0196-0644(80)80475-6. Ann Emerg Med. 1980. PMID: 7447101
-
Tissue distribution of lidocaine after fatal accidental injection.J Forensic Sci. 1984 Oct;29(4):1229-36. J Forensic Sci. 1984. PMID: 6502118
-
Lidocaine and seizures.Ther Drug Monit. 2000 Jun;22(3):320-2. doi: 10.1097/00007691-200006000-00014. Ther Drug Monit. 2000. PMID: 10850400 Review.
-
Lidocaine overdose: another preventable case?Pediatr Emerg Care. 1994 Dec;10(6):344-6. doi: 10.1097/00006565-199412000-00011. Pediatr Emerg Care. 1994. PMID: 7899121 Review.
Cited by
-
Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures.Clin Pharmacokinet. 2011 Jul;50(7):461-9. doi: 10.2165/11589160-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21651313
-
Benefit and risks of local anesthetics in infants and children.Paediatr Drugs. 2002;4(10):649-72. doi: 10.2165/00128072-200204100-00003. Paediatr Drugs. 2002. PMID: 12269841 Review.
-
Acute Lidocaine Toxicity; a Case Series.Emerg (Tehran). 2018;6(1):e38. Epub 2018 Jun 16. Emerg (Tehran). 2018. PMID: 30009240 Free PMC article.
-
Clinical features, pathogenesis and management of drug-induced seizures.Drug Saf. 1990 Mar-Apr;5(2):109-51. doi: 10.2165/00002018-199005020-00004. Drug Saf. 1990. PMID: 2182049 Review.
-
Poisoning due to class 1B antiarrhythmic drugs. Lignocaine, mexiletine and tocainide.Med Toxicol Adverse Drug Exp. 1989 Nov-Dec;4(6):412-28. doi: 10.1007/BF03259923. Med Toxicol Adverse Drug Exp. 1989. PMID: 2513464 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials