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. 2023 May;29(5):1007-1010.
doi: 10.3201/eid2905.221887. Epub 2023 Apr 5.

Emerging Invasive Group A Streptococcus M1UK Lineage Detected by Allele-Specific PCR, England, 20201

Xiangyun Zhi, Ho Kwong Li, Hanqi Li, Zuzanna Loboda, Samson Charles, Ana Vieira, Kristin Huse, Elita Jauneikaite, Lucy Reeves, Kai Yi Mok, Juliana Coelho, Theresa Lamagni, Shiranee Sriskandan

Emerging Invasive Group A Streptococcus M1UK Lineage Detected by Allele-Specific PCR, England, 20201

Xiangyun Zhi et al. Emerg Infect Dis. 2023 May.

Abstract

Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1UK. An allele-specific PCR was developed to distinguish M1UK from other emm1 strains. The M1UK lineage represented 91% of invasive emm1 isolates in England in 2020. Allele-specific PCR will permit surveillance for M1UK without need for genome sequencing.

Keywords: England; M1UK; PCR; Streptococcus pyogenes; allele-specific; bacteria; emerging lineage; emm1; group A Streptococcus; iGAS; molecular diagnostics; respiratory infections; scarlet fever; streptococci; superantigen.

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Figures

Figure 1
Figure 1
Countries and US states with reported M1UK Streptococcus pyogenes cases. Map created by using MapChart (https://www.mapchart.net) as part of a study of emerging invasive group A Streptococcus M1UK lineage detected by allele-specific PCR, England, 2020.
Figure 2
Figure 2
Prevalence of M1UK and M1global Streptococcus pyogenes lineages over time in study of emerging invasive group A Streptococcus M1UK lineage detected by allele-specific PCR, England, 2020. We determined percentages of emm1 isolates in England that belonged to M1UK or M1global lineages by using all available emm1 S. pyogenes genome sequences for 2007–2016 (4) and all available invasive isolates from 2020 that we tested by allele-specific PCR. Numbers on graph indicate number of isolates assigned as M1UK/total number sequenced for each year. Graph was adapted and updated from data previously described (4).
See this image and copyright information in PMC

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