Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jun;58(3):975-8.
doi: 10.1128/JVI.58.3.975-978.1986.

Clonal origins of lymphoproliferative disease induced by Epstein-Barr virus

N A Brown, C Liu, C R Garcia, Y F Wang, A Griffith, R S Sparkes, K L Calame

Clonal origins of lymphoproliferative disease induced by Epstein-Barr virus

N A Brown et al. J Virol. 1986 Jun.

Abstract

Analysis of immunoglobulin gene rearrangements in 16 B-cell lineages clonally propagated from two mononucleosis patients supported the notion that mononucleosis is a polyclonal B-lymphoproliferative disorder. Three of seven cell clones from a patient with a fatal B lymphoma revealed the same pattern of immunoglobulin gene rearrangement, indicating that this patient's disease was oligoclonal. The three similar clones were propagated from two sites (blood and spleen), indicating that they represent a metastatic cell lineage which arose during the patient's fatal B lymphoproliferation.

PubMed Disclaimer

References

    1. N Engl J Med. 1980 Jun 5;302(23):1293-7 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3683-7 - PubMed
    1. Nature. 1981 Apr 2;290(5805):368-72 - PubMed

Publication types

Substances