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. 2023 May;20(5):e202300338.
doi: 10.1002/cbdv.202300338. Epub 2023 Apr 26.

Guaiane-Type Sesquiterpenes from the Stems of Fissistigma oldhamii

Mei-Zhu Wu  1   2 , Bing-Quan Xu  1   2 , Xiao-Zheng Zhang  1   2 , Sha Liu  1   2 , You-Ping Luo  1   2 , Xue-Ming Zhou  1   2 , Guang-Ying Chen  1   2
Affiliations

Guaiane-Type Sesquiterpenes from the Stems of Fissistigma oldhamii

Mei-Zhu Wu et al. Chem Biodivers. 2023 May.

Abstract

Two new guaiane-type sesquiterpenes dysodensiols J and L, one new natural product dysodensiol K together with four known biogenetically related guaiane-type sesquiterpenes were isolated from the stems of Fissistigma oldhamii. Their structures were elucidated by detailed analysis of NMR, HR-ESI-MS, IR and Optical rotations data. Compound 1 contains an uncommon five-membered ether ring. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed inhibitory activity with an IC50 value of 6.8 μM. Compounds 5-7 exhibited moderate inhibitory activity with IC50 values of 23.8, 26.6, and 27.1 μM, respectively.

Keywords: Fissistigma oldhamii; norisoprenoid; sesquiterpene; synoviocytes.

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