Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul;60(7):4064-4083.
doi: 10.1007/s12035-023-03321-y. Epub 2023 Apr 5.

Non-coding RNAs and Exosomal Non-coding RNAs in Traumatic Brain Injury: the Small Player with Big Actions

Omid Mohamadzadeh  1 , Mahsasadat Hajinouri  2 , Farzaneh Moammer  3 , Seyed Saeed Tamehri Zadeh  4 , Ghoncheh Omid Shafiei  5 , Ameneh Jafari  6   7 , Amirreza Ostadian  8 , Sayyed Alireza Talaei Zavareh  9 , Michael R Hamblin  10 , Arezoo Jafarian Yazdi  11 , Amirhossein Sheida  12   13 , Hamed Mirzaei  14
Affiliations
Review

Non-coding RNAs and Exosomal Non-coding RNAs in Traumatic Brain Injury: the Small Player with Big Actions

Omid Mohamadzadeh et al. Mol Neurobiol. 2023 Jul.

Abstract

Nowadays, there is an increasing concern regarding traumatic brain injury (TBI) worldwide since substantial morbidity is observed after it, and the long-term consequences that are not yet fully recognized. A number of cellular pathways related to the secondary injury in brain have been identified, including free radical production (owing to mitochondrial dysfunction), excitotoxicity (regulated by excitatory neurotransmitters), apoptosis, and neuroinflammatory responses (as a result of activation of the immune system and central nervous system). In this context, non-coding RNAs (ncRNAs) maintain a fundamental contribution to post-transcriptional regulation. It has been shown that mammalian brains express high levels of ncRNAs that are involved in several brain physiological processes. Furthermore, altered levels of ncRNA expression have been found in those with traumatic as well non-traumatic brain injuries. The current review highlights the primary molecular mechanisms participated in TBI that describes the latest and novel results about changes and role of ncRNAs in TBI in both clinical and experimental research.

Keywords: Exosome; Long non-coding RNAs; MicroRNAs; Non-coding RNA; Traumatic brain injury.

PubMed Disclaimer

References

    1. Timofeev I, Santarius T, Kolias AG, Hutchinson PJ (2012) Decompressive craniectomy - operative technique and perioperative care. Adv Tech Stand Neurosurg 38:115–136 - PubMed - DOI
    1. Faul M, Wald MM, Xu L, Coronado VG (2010) Traumatic brain injury in the United States. Emergency department visits, hospitalizations, and deaths 2002–2006
    1. Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A et al (2017) Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. The Lancet Neurology 16(12):987–1048 - PubMed - DOI
    1. National Institute for Health and Care Excellence (NICE) (2017) Head injury: assessment and early management. Clinical guideline [CG176]. London, NICE
    1. Huber A, Dorn A, Witzmann A, Cervós-Navarro J (1993) Microthrombi formation after severe head trauma. Int J Legal Med 106(3):152–155 - PubMed - DOI

LinkOut - more resources