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Meta-Analysis
. 2023 Apr 5;24(1):267.
doi: 10.1186/s12891-023-06331-y.

Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis

Mingwei Hu  1 , Yifan Zhang  1 , Guangqian Shang  1 , Jianjun Guo  1 , Hao Xu  1 , Xue Ma  1 , Xue Yang  2 , Shuai Xiang  3
Affiliations
Meta-Analysis

Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis

Mingwei Hu et al. BMC Musculoskelet Disord. .

Abstract

Purpose: To compare the effect of vancomycin presoak treatment of grafts during anterior cruciate ligament reconstruction on the incidence of postoperative infection or septic arthritis.

Methods: Studies published before May 3, 2022 investigating vancomycin presoak of grafts during anterior cruciate ligament reconstruction were searched in the PubMed and Cochrane Central Register of Controlled Trials. Studies were screened, and data on the incidence of postoperative infection or septic arthritis were extracted and included in the analysis.

Results: Thirteen studies were included for analysis after search screening, yielding a total of 31,150 participants for analysis, of whom 11,437 received graft vancomycin presoak treatment, and 19,713 did not receive treatment. Participants who received vancomycin treatment had significantly lower infection rates (0.09% versus 0.74%; OR 0.17; 95% CI 0.10, 0.30; P < 0.00001).

Conclusion: Pre-soaking of the graft with vancomycin during ACL reconstruction reduced the incidence of postoperative infection and septic arthritis.

Keywords: Anterior cruciate ligament reconstruction; Antibiotic; Infection; Sports medicine; vancomycin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
The selection process for inclusion and exclusion of articles
Fig. 2
Fig. 2
Forest plot of postoperative infection differences between ACL grafts soaked in vancomycin, and grafts not treated with vancomycin
See this image and copyright information in PMC

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