Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 5;24(1):266.
doi: 10.1186/s12891-023-06376-z.

Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty

Yi Deng  1   2 , Paul N Smith  3   4 , Rachel W Li  4   5
Affiliations

Diabetes mellitus is a potential risk factor for aseptic loosening around hip and knee arthroplasty

Yi Deng et al. BMC Musculoskelet Disord. .

Abstract

Background: Aseptic loosening is a leading cause of revision following total hip and knee arthroplasty which is caused by chronic inflammation around the prosthesis. Diabetes mellitus causes systemic inflammatory changes which could increase the risk of aseptic loosening. This study investigated the association between diabetes mellitus and aseptic loosening around hip and knee arthroplasty.

Methods: A case-control study was conducted at a single arthroplasty centre over the seven-year period of January 2015 to December 2021. Cases were defined as any adult patient undergoing revision hip or knee arthroplasty for aseptic loosening. Controls were randomly selected patients undergoing primary total hip or knee arthroplasty during the same period at a 1:4 ratio. Risk factors were compared between the two groups.

Results: A total of 440 patients were included in our study - 88 in the aseptic loosening group and 352 patients in the control group. The odds of having diabetes mellitus in the aseptic loosening group was 2.78 (95%CI 1.31-5.92, P = 0.01). Other risk factors were not significantly different between the two groups.

Conclusions: The incidence of diabetes mellitus is significantly greater in patients undergoing revision arthroplasty for aseptic loosening. Further research is required to explore whether this association is indeed causative.

Keywords: Arthroplasty; Aseptic loosening; Diabetes mellitus; Inflammation; Osteolysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow of patients through study
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Moretti L, Coviello M, Rosso F, Calafiore G, Monaco E, Berruto M, Solarino G. Current Trends in Knee Arthroplasty: Are Italian Surgeons Doing What Is Expected? Medicina (Kaunas) 2022, 58(9). - PMC - PubMed
    1. Munger P, Roder C, Ackermann-Liebrich U, Busato A. Patient-related risk factors leading to aseptic stem loosening in total hip arthroplasty: a case-control study of 5,035 patients. Acta Orthop. 2006;77(4):567–74. doi: 10.1080/17453670610012629. - DOI - PubMed
    1. Maradit Kremers H, Schleck CD, Lewallen EA, Larson DR, Van Wijnen AJ, Lewallen DG. Diabetes Mellitus and Hyperglycemia and the risk of aseptic loosening in total joint arthroplasty. J Arthroplasty. 2017;32(9S):251–S253. doi: 10.1016/j.arth.2017.02.056. - DOI - PubMed
    1. Levent A, Suero EM, Gehrke T, Citak M. Risk factors for aseptic loosening after total knee arthroplasty with a Rotating-Hinge Implant: a case-control study. J Bone Joint Surg Am. 2021;103(6):517–23. doi: 10.2106/JBJS.20.00788. - DOI - PubMed
    1. Ong KL, Lau E, Suggs J, Kurtz SM, Manley MT. Risk of subsequent revision after primary and revision total joint arthroplasty. Clin Orthop Relat Res. 2010;468(11):3070–6. doi: 10.1007/s11999-010-1399-0. - DOI - PMC - PubMed