Carbamylation in Uremia

Affiliations

Editorial

Thomas Hostetter. J Am Soc Nephrol. 2023.

. 2023 May 1;34(5):731-732.

doi: 10.1681/ASN.0000000000000106. Epub 2023 Apr 5.

¹ Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Abstract

This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2023_04_24_JSN_URE_EP22_042423.mp3.

Protein Carbamylation and the Risk of ESKD in Patients with CKD.
Kalim S, Zhao S, Tang M, Rhee EP, Allegretti AS, Nigwekar S, Karumanchi SA, Lash JP, Berg AH. Kalim S, et al. J Am Soc Nephrol. 2023 May 1;34(5):876-885. doi: 10.1681/ASN.0000000000000078. Epub 2023 Jan 21. J Am Soc Nephrol. 2023. PMID: 36757153 Free PMC article.

1. Dirnhuber P, Schutz F. The isomeric transformation of urea into ammonium cyanate in aqueous solutions. Biochem J. 1948;42(4):628–632. doi:10.1042/bj0420628 - DOI - PubMed
1. Stark GR. On the reversible reaction of cyanate with sulfhydryl groups and the determination of NH2-terminal cysteine and cystine in proteins. J Biol Chem. 1964;239(5):1411–1414. doi:10.1016/s0021-9258(18)91330-x - DOI - PubMed
1. Johnson WJ, Hagge WW, Wagoner RD, Dinapoli RP, Rosevear JW. Effects of urea loading in patients with far advanced renal failure. Mayo Clin Proc. 1972;47(1):21–29. - PubMed
1. Kalim S, Zhao S, Rhee E, et al. . Protein carbamylation and the risk of ESKD in patients with CKD. J Am Soc Nephrol. 2023;34(5):876–885. doi:10.1681/ASN.0000000000000078 - DOI - PMC - PubMed
1. Cerami A, Manning JM. Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro. Proc Natl Acad Sci. 1971;68(6):1180–1183. doi:10.1073/pnas.68.6.1180 - DOI - PMC - PubMed