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Review
. 2023 Nov;131(11):654-667.
doi: 10.1111/apm.13316. Epub 2023 Apr 25.

Invasive pulmonary aspergillosis in the intensive care unit: current challenges and best practices

Sarah Gaffney  1 , Dearbhla M Kelly  1 , Puteri Maisarah Rameli  1 , Eoin Kelleher  2 , Ignacio Martin-Loeches  1   3   4
Affiliations
Review

Invasive pulmonary aspergillosis in the intensive care unit: current challenges and best practices

Sarah Gaffney et al. APMIS. 2023 Nov.

Abstract

The prevalence of invasive pulmonary aspergillosis (IPA) is growing in critically ill patients in the intensive care unit (ICU). It is increasingly recognized in immunocompetent hosts and immunocompromised ones. IPA frequently complicates both severe influenza and severe coronavirus disease 2019 (COVID-19) infection. It continues to represent both a diagnostic and therapeutic challenge and can be associated with significant morbidity and mortality. In this narrative review, we describe the epidemiology, risk factors and disease manifestations of IPA. We discuss the latest evidence and current published guidelines for the diagnosis and management of IPA in the context of the critically ill within the ICU. Finally, we review influenza-associated pulmonary aspergillosis (IAPA), COVID-19-associated pulmonary aspergillosis (CAPA) as well as ongoing and future areas of research.

Keywords: Invasive aspergillosis; antifungal therapy; fungal infection.

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References

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