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Editorial
. 2023 Apr 6;141(14):1653-1655.
doi: 10.1182/blood.2022019244.

Silencing with SAFB: a new role for HOXA9 in AML

Aniruddha J Deshpande  1 , Nan Zhu  2   3
Affiliations
Editorial

Silencing with SAFB: a new role for HOXA9 in AML

Aniruddha J Deshpande et al. Blood. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
A model of HOXA9 transcriptional activity in AML. (Top) HOXA9 heterodimerizes with MEIS/PBX proteins to promote activation of oncogenic signaling. Transcriptional activation may involve coactivators such as MLL3/4, proteins that modify chromatin to activate gene expression. (Bottom) A novel mechanism of HOXA9-mediated gene repression described in this study. HOXA9 interacts with the SAFB to repress differentiation-associated genes in leukemia cells. HOXA9 through SAFB recruits corepressors NuRD and HP1γ, proteins that modify chromatin to repress gene expression. Figure created with BioRender.com.
See this image and copyright information in PMC

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References

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