Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May;27(2):187-210.
doi: 10.1016/j.cld.2023.01.002. Epub 2023 Feb 26.

Metabolic Syndrome and Its Association with Nonalcoholic Steatohepatitis

Fernando Bril  1 , Arun Sanyal  2 , Kenneth Cusi  3
Affiliations
Review

Metabolic Syndrome and Its Association with Nonalcoholic Steatohepatitis

Fernando Bril et al. Clin Liver Dis. 2023 May.

Abstract

The relationship between insulin resistance, metabolic syndrome (MetS), and nonalcoholic fatty liver disease (NAFLD) is complicated. Although insulin resistance is almost universal in people with NAFLD and MetS, NAFLD may be present without features of MetS and vice versa. While NAFLD has a strong correlation with cardiometabolic risk factors, these are not intrinsic components of this condition. Taken together, our knowledge gaps call for caution regarding the common assertion that NAFLD is the hepatic manifestation of the MetS, and for defining NAFLD in broad terms as a "metabolic dysfunction" based on a diverse and poorly understood constellation of cardiometabolic features.

Keywords: Diabetes; Insulin resistance; NASH; Obesity; Treatment of type 2 diabetes.

PubMed Disclaimer

MeSH terms