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. 2023 Jun;39(3):151407.
doi: 10.1016/j.soncn.2023.151407. Epub 2023 Apr 4.

Symptom Cluster Experiences of Patients Operated for Oral Cancer: A Mixed Methods Study

Asha Mathew  1 , Mark B Lockwood  2 , Alana Steffen  3 , Amit Jiwan Tirkey  4 , Simon P Pavamani  5 , Crystal L Patil  6 , Ardith Z Doorenbos  7
Affiliations

Symptom Cluster Experiences of Patients Operated for Oral Cancer: A Mixed Methods Study

Asha Mathew et al. Semin Oncol Nurs. 2023 Jun.

Abstract

Objective: This convergent mixed methods study aimed to obtain a comprehensive understanding of symptom cluster experiences in patients with oral cancer. Survey and phenomenological interviews were conducted in parallel to identify distinct patient subgroups based on symptom cluster experiences along with their predictors and explore experiences of living with symptom clusters, respectively.

Data sources: A convenience sample of 300 patients with oral cancer who had completed surgery provided the quantitative data, and a maximum variation purposive subsample of 20 participants, drawn from the survey sample, provided the qualitative data. Agglomerative hierarchical cluster analysis was used to identify subgroups, multivariate analyses were done to identify predictors, and thematic analysis was used for patient narratives.

Conclusion: Almost 94% of the survey participants had two or more co-occurring symptoms. The four most severe and prevalent symptoms were dysphagia, problems with teeth or gums, speech difficulty, and dry mouth. A distinct subgroup consisting of 61% of patients reported severe dysphagia and teeth problems, which was associated with age, oral cancer stage and site. Interviews revealed the causes and the context influencing the perception and response to these symptoms. Thus, the quantitative data provided information on severity and patient subgroups based on symptom cluster experiences, while the qualitative data validated these conclusions and additionally provided in-depth details and meaningful insight on perceived causes and contextual influences of their experiences. This comprehensive picture of symptom cluster experiences can aid in the development of patient-centered interventions for people with oral cancer.

Implications for nursing practice: An interdisciplinary approach to targeting concurrent symptoms incorporating psychological and physical interventions is necessary. Older patients treated for Stage IV cancers and for buccal mucosa tumors are at high-risk of having severe dysphagia postoperatively, and these patients should be targeted for dysphagia interventions. The contextual factors play an important role in developing patient-centered interventions.

Keywords: Hierarchical cluster analysis; Mixed methods; Oral cancer; Patient subgroups; Symptom cluster.

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Conflict of interest statement

Declaration of Competing Interests

No authors have any financial relationships or conflicts of interests to disclose.

Figures

Figure 1
Figure 1
Dendrogram Illustrating Clustering of Patients (N =300) Note: G1-G10 refer to subgroups of patients
Figure 2
Figure 2
Context of Symptom Cluster Experiences in Oral Cancer
See this image and copyright information in PMC

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