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Clinical Trial
. 2023 Apr 6;13(1):3.
doi: 10.1038/s41387-023-00234-6.

A scalable, virtual weight management program tailored for adults with type 2 diabetes: effects on glycemic control

John W Apolzan  1 , Jessica Gokee LaRose  2 , Stephen D Anton  3 , Robbie A Beyl  4 , Frank L Greenway  4 , Edmond P Wickham 3rd  2 , Autumn Lanoye  2 , Melissa N Harris  4 , Corby K Martin  4 , Tiffany Bullard  5 , Gary D Foster  5   6 , Michelle I Cardel  5   7   8
Affiliations
Clinical Trial

A scalable, virtual weight management program tailored for adults with type 2 diabetes: effects on glycemic control

John W Apolzan et al. Nutr Diabetes. .

Abstract

Background: The objective was to test the efficacy of a scalable, virtually delivered, diabetes-tailored weight management program on glycemic control in adults with type 2 diabetes (T2D).

Methods: This was a single arm, three-site clinical trial. Participants had baseline HbA1c between 7-11% and BMI between 27-50 kg/m2. Primary outcome was change in HbA1c at 24 weeks. Secondary outcomes were changes in body weight, waist circumference, the Diabetes Distress Scale (DDS), quality of life (IWQOL-L), and hunger (VAS). Generalized linear effects models were used for statistical analysis.

Results: Participants (n = 136) were 56.8 ± 0.8 y (Mean ± SEM), 36.9 ± 0.5 kg/m2, 80.2% female, 62.2% non-Hispanic white. Baseline HbA1c, weight, and total DDS score were 8.0 ± 0.09%, 101.10 ± 1.47 kg, and 2.35 ± 0.08, respectively. At week 24, HbA1c, body weight, and total DDS decreased by 0.75 ± 0.11%, 5.74 ± 0.50%, 0.33 ± 0.10 units, respectively (all p < 0.001). Also, at week 24, quality of life increased by 9.0 ± 1.2 units and hunger decreased by 14.3 ± 2.4 units, (both p < 0.0001).

Conclusions: The scalable, virtually delivered T2D-tailored weight management program had favorable and clinically meaningful effects on glycemic control, body weight, and psychosocial outcomes.

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Conflict of interest statement

JWA: Grants NIH NIDDK and NIMHD, NSF, and USDA. JGL: Grants NIH NIDDK. FLG: Consultant: Ed Med Resources, NovMeta Pharma, GNC, Basic Research, Scientific Advisory Board: Altimune, Pfizer, Nutraceutical Corporation, Stock/stock options: UR Labs, Plensat, Ketogenic Health Systems, Slim Health Nutrition, Energesis, Rejuvenate Bio, Patents: Melior Discoveries (Tolimidone/menthol). Grants: NovMeta Pharma. GDF: Employee and Shareholder at WW. MIC: Grants: National Institute of Health NHLBI and NIDDK. Stock/Stock Options: WW International, Inc. Employee at WW International, Inc. The authors declare no other competing interests.

Figures

Fig. 1
Fig. 1. CONSORT Diagram.
Not all persons performed Web Screening. Study was performed from April 2021 till December 2021 in Baton Rouge, Louisiana; Richmond, Virginia; and Gainesville, Florida.
See this image and copyright information in PMC

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