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Comment
. 2023 May;19(5):257.
doi: 10.1038/s41584-023-00963-z.

Mitochondrial fumarate implicated in inflammation

Sarah Onuora  1
Affiliations
Comment

Mitochondrial fumarate implicated in inflammation

Sarah Onuora. Nat Rev Rheumatol. 2023 May.
No abstract available

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Comment on

  • Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
    Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, Yin M, Montano EN, Huo L, Toller-Kawahisa JE, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa ASH, De Los Santos G, Ishimori M, Wallace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C, O'Neill LAJ. Hooftman A, et al. Nature. 2023 Mar;615(7952):490-498. doi: 10.1038/s41586-023-05720-6. Epub 2023 Mar 8. Nature. 2023. PMID: 36890227 Free PMC article.

References

Original article
    1. Hooftman, A. et al. Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature 615, 490–498 (2023) - DOI - PubMed
Related article
    1. Zecchini, V. et al. Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature 615, 499–506 (2023) - DOI - PubMed - PMC

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