Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank

Yi Zhang^#¹, Shi-Dong Chen^#¹, Yue-Ting Deng¹, Jia You^{2

3

4}, Xiao-Yu He¹, Xin-Rui Wu¹, Bang-Sheng Wu¹, Liu Yang¹, Ya-Ru Zhang¹, Kevin Kuo¹, Jian-Feng Feng^{2

3

4

5}, Wei Cheng^{1

2

3

4}, John Suckling⁶, A David Smith⁷, Jin-Tai Yu⁸

Affiliations

¹ Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.
² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
³ Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, China.
⁴ Fudan ISTBI-ZJNU Algorithm Centre for Brain-Inspired Intelligence, Zhejiang Normal University, Jinhua, China.
⁵ MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
⁶ Department of Psychiatry, University of Cambridge, Cambridge, UK.
⁷ Department of Pharmacology, University of Oxford, Oxford, UK.
⁸ Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China. jintai_yu@fudan.edu.cn.

^# Contributed equally.

PMID: 37024724
DOI: 10.1038/s41562-023-01585-x

Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank

Yi Zhang et al. Nat Hum Behav. 2023 Jul.

. 2023 Jul;7(7):1185-1195.

doi: 10.1038/s41562-023-01585-x. Epub 2023 Apr 6.

Authors

Affiliations

¹ Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China.
² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
³ Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, China.
⁴ Fudan ISTBI-ZJNU Algorithm Centre for Brain-Inspired Intelligence, Zhejiang Normal University, Jinhua, China.
⁵ MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
⁶ Department of Psychiatry, University of Cambridge, Cambridge, UK.
⁷ Department of Pharmacology, University of Oxford, Oxford, UK.
⁸ Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai, China. jintai_yu@fudan.edu.cn.

^# Contributed equally.

PMID: 37024724
DOI: 10.1038/s41562-023-01585-x

Abstract

Previous hypothesis-driven research has identified many risk factors linked to dementia. However, the multiplicity and co-occurrence of risk factors have been underestimated. Here we analysed data of 344,324 participants from the UK Biobank with 15 yr of follow-up data for 210 modifiable risk factors. We first conducted an exposure-wide association study and then combined factors associated with dementia to generate composite scores for different domains. We then evaluated their joint associations with dementia in a multivariate Cox model. We estimated the potential impact of eliminating the unfavourable profiles of risk domains on dementia using population attributable fraction. The associations varied by domain, with lifestyle (16.6%), medical history (14.0%) and socioeconomic status (13.5%) contributing to the majority of dementia cases. Overall, we estimated that up to 47.0%-72.6% of dementia cases could be prevented.

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References

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Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank

Affiliations

Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical