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Review
. 2023 Aug;23(4):986-996.
doi: 10.3758/s13415-023-01093-5. Epub 2023 Apr 6.

Targeting the function of the transentorhinal cortex to identify early cognitive markers of Alzheimer's disease

Christine Bastin  1 , Emma Delhaye  2   3
Affiliations
Review

Targeting the function of the transentorhinal cortex to identify early cognitive markers of Alzheimer's disease

Christine Bastin et al. Cogn Affect Behav Neurosci. 2023 Aug.

Abstract

Initial neuropathology of early Alzheimer's disease accumulates in the transentorhinal cortex. We review empirical data suggesting that tasks assessing cognitive functions supported by the transenthorinal cortex are impaired as early as the preclinical stages of Alzheimer's disease. These tasks span across various domains, including episodic memory, semantic memory, language, and perception. We propose that all tasks sensitive to Alzheimer-related transentorhinal neuropathology commonly rely on representations of entities supporting the processing and discrimination of items having perceptually and conceptually overlapping features. In the future, we suggest a screening tool that is sensitive and specific to very early Alzheimer's disease to probe memory and perceptual discrimination of highly similar entities.

Keywords: Alzheimer’s disease; Cognitive markers; Mild cognitive impairment; Neuropsychology; Transentorhinal cortex.

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