Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 21:11:1158749.
doi: 10.3389/fbioe.2023.1158749. eCollection 2023.

Gelatin-based anticancer drug delivery nanosystems: A mini review

Xianchao Jiang  1 , Zhen Du  1 , Xinran Zhang  1 , Fakhar Zaman  1 , Zihao Song  1 , Yuepeng Guan  2 , Tengfei Yu  3 , Yaqin Huang  1
Affiliations
Review

Gelatin-based anticancer drug delivery nanosystems: A mini review

Xianchao Jiang et al. Front Bioeng Biotechnol. .

Abstract

Drug delivery nanosystems (DDnS) is widely developed recently. Gelatin is a high-potential biomaterial originated from natural resources for anticancer DDnS, which can effectively improve the utilization of anticancer drugs and reduce side effects. The hydrophilic, amphoteric behavior and sol-gel transition of gelatin can be used to fulfill various requirements of anticancer DDnS. Additionally, the high number of multifunctional groups on the surface of gelatin provides the possibility of crosslinking and further modifications. In this review, we focus on the properties of gelatin and briefly elaborate the correlation between the properties and anticancer DDnS. Furthermore, we discuss the applications of gelatin-based DDnS in various cancer treatments. Overall, we have summarized the excellent properties of gelatin and correlated with DDnS to provide a manual for the design of gelatin-based materials for DDnS.

Keywords: anticancer; biomaterials; drug delivery; gelatin; nanosystems.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Properties of gelatin used in anticancer DDnS.
FIGURE 2
FIGURE 2
Application of gelatin DDnS in anticancer field. (A) The effect of pH on the drug release rate of gelatin DDnS (Bhattacharyya et al., 2022); (B) The effect of temperature on the drug release rate of gelatin DDnS (Suarasan et al., 2016); (C) Application of MMP-2 responsiveness of gelatin in anticancer DDnS (Hu et al., 2015).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abdelrady H., Hathout R. M., Osman R., Saleem I., Mortada N. D. (2019). Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy. Eur. J. Pharm. Sci. 133, 115–126. 10.1016/j.ejps.2019.03.016 - DOI - PubMed
    1. Anirudhan T. S., Mohan A. M. (2014). Novel pH switchable gelatin based hydrogel for the controlled delivery of the anti cancer drug 5-fluorouracil. RSC Adv. 4 (24), 12109–12118. 10.1039/C3RA47991A - DOI
    1. Augustine R., Zahid A. A., Mraiche F., Alam K., Al Moustafa A.-E., Hasan A. (2021). Gelatin-methacryloyl hydrogel based in vitro blood–brain barrier model for studying breast cancer-associated brain metastasis. Pharm. Dev. Technol. 26 (4), 490–500. 10.1080/10837450.2021.1872624 - DOI - PubMed
    1. Benjamin A. S., Remya V., Raj N. A. N., Nayak S. (2022). Evaluation of doxorubicin loaded gelatin coated iron oxide nanoparticles for drug delivery and magnetic hyperthermia for anti-cancer treatment. Trends Biomaterials Artif. Organs 36, 3+.
    1. Bhattacharyya S. K., Dule M., Paul R., Dash J., Anas M., Mandal T. K., et al. (2020). Carbon Dot cross-linked gelatin nanocomposite hydrogel for pH-sensing and pH-responsive drug delivery. ACS Biomaterials Sci. Eng. 6 (10), 5662–5674. 10.1021/acsbiomaterials.0c00982 - DOI - PubMed

LinkOut - more resources