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Comment
. 2023 Apr 14;8(82):eadg7526.
doi: 10.1126/sciimmunol.adg7526. Epub 2023 Apr 7.

The expanding family of T follicular regulatory cells

Luis Graca  1 , Johanne Jacobsen  2 , Saumya Kumar  3
Affiliations
Comment

The expanding family of T follicular regulatory cells

Luis Graca et al. Sci Immunol. .

Abstract

The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses in providing optimal antibody production and preventing events leading to autoimmunity (see the related Research Article by Le Coz et al.).

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  • Human T follicular helper clones seed the germinal center-resident regulatory pool.
    Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N. Le Coz C, et al. Sci Immunol. 2023 Apr 14;8(82):eade8162. doi: 10.1126/sciimmunol.ade8162. Epub 2023 Apr 7. Sci Immunol. 2023. PMID: 37027481 Free PMC article.

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