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Comment
. 2023 Apr 6;83(7):1022-1023.
doi: 10.1016/j.molcel.2023.02.019.

Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation

Zhongyu Zou  1 , Chuan He  2
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Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation

Zhongyu Zou et al. Mol Cell. .
Free article

Abstract

In this issue, Cieśla et al.1 report a translation regulation through ALKBH5-mediated 5'-UTR m6A demethylation of the SF3B1 transcript during leukemic transformation. The SF3B1 protein maintains efficient splicing and expression of transcripts encoding DNA damage repair components to restrain excessive DNA damage.

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Conflict of interest statement

Declaration of interests C.H. is a scientific founder and a scientific advisory board member of Accent Therapeutics, Inc., Aferna Green, Inc., and AccuraDX, Inc.

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