LncRNA CASC19: a novel oncogene involved in human cancer

Shidong Wang^{1

2

3}, Chen Qiao^{1

2

3}, Rui Fang^{1

2

3}, Shuyue Yang^{1

2

3}, Guiping Zhao^{1

2

3}, Si Liu^{4

5

6}, Peng Li^{7

8

9}

Affiliations

¹ Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
² Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, 100050, China.
³ National Clinical Research Center for Digestive Diseases, Beijing, 100050, China.
⁴ Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. liusi@ccmu.edu.cn.
⁵ Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, 100050, China. liusi@ccmu.edu.cn.
⁶ National Clinical Research Center for Digestive Diseases, Beijing, 100050, China. liusi@ccmu.edu.cn.
⁷ Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. lipeng@ccmu.edu.cn.
⁸ Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, 100050, China. lipeng@ccmu.edu.cn.
⁹ National Clinical Research Center for Digestive Diseases, Beijing, 100050, China. lipeng@ccmu.edu.cn.

PMID: 37029242
DOI: 10.1007/s12094-023-03165-x

Review

LncRNA CASC19: a novel oncogene involved in human cancer

Shidong Wang et al. Clin Transl Oncol. 2023 Oct.

. 2023 Oct;25(10):2841-2851.

doi: 10.1007/s12094-023-03165-x. Epub 2023 Apr 7.

Authors

Shidong Wang^{1

2

3}, Chen Qiao^{1

2

3}, Rui Fang^{1

2

3}, Shuyue Yang^{1

2

3}, Guiping Zhao^{1

2

3}, Si Liu^{4

5

6}, Peng Li^{7

8

9}

Affiliations

¹ Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
² Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, 100050, China.
³ National Clinical Research Center for Digestive Diseases, Beijing, 100050, China.
⁴ Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. liusi@ccmu.edu.cn.
⁵ Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, 100050, China. liusi@ccmu.edu.cn.
⁶ National Clinical Research Center for Digestive Diseases, Beijing, 100050, China. liusi@ccmu.edu.cn.
⁷ Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. lipeng@ccmu.edu.cn.
⁸ Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, 100050, China. lipeng@ccmu.edu.cn.
⁹ National Clinical Research Center for Digestive Diseases, Beijing, 100050, China. lipeng@ccmu.edu.cn.

PMID: 37029242
DOI: 10.1007/s12094-023-03165-x

Abstract

Multiple studies have shown that long non-coding RNAs (lncRNAs) play an important role in the occurrence and development of diverse cancers. Cancer susceptibility candidate 19 (CASC19), encoded by chromosome 8q24.21, is a newly discovered lncRNA that contains 324 nucleotides. CASC19 has been found to be significantly overexpressed in different human cancers, such as non-small cell lung carcinoma, gastric cancer, colorectal cancer, pancreatic cancer, clear cell renal cell carcinoma, glioma, cervical cancer, and nasopharyngeal carcinoma. Moreover, dysregulation of CASC19 was closely associated with clinicopathological parameters and cancer progression. CASC19 regulates a variety of cell phenotypes, including cell proliferation, apoptosis, cell cycle, migration, invasion, epithelial-mesenchymal transition, autophagy, and therapeutic resistance. In this study, we review recent studies on the characteristics and biological function of CASC19, as well as its role in human cancers. These findings suggest that CASC19 may be both a reliable biomarker and a potential therapeutic target in cancers.

Keywords: Biomarker; CASC19; Cancer; Long non-coding RNA; Therapeutic target.

PubMed Disclaimer

Cited by

Role of long non-coding RNA in chemoradiotherapy resistance of nasopharyngeal carcinoma.
Yang Y, Yuan Q, Tang W, Ma Y, Duan J, Yang G, Fang Y. Yang Y, et al. Front Oncol. 2024 Feb 29;14:1346413. doi: 10.3389/fonc.2024.1346413. eCollection 2024. Front Oncol. 2024. PMID: 38487724 Free PMC article. Review.
The ceRNA Regulatory Network in Vitiligo: Evidence from Bioinformatics Analysis.
Yang H, Li X, Zhang X, Ge Y, Yang Y, Lin T. Yang H, et al. Clin Cosmet Investig Dermatol. 2025 Aug 30;18:2067-2077. doi: 10.2147/CCID.S528604. eCollection 2025. Clin Cosmet Investig Dermatol. 2025. PMID: 40910032 Free PMC article.
Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression.
Yu LH, Zhang GL. Yu LH, et al. J Cardiovasc Transl Res. 2024 Jun 10. doi: 10.1007/s12265-024-10530-w. Online ahead of print. J Cardiovasc Transl Res. 2024. PMID: 38858339 Review.
Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis.
Yari M, Eidi M, Omrani MA, Fazeli Z, Rahmanian M, Ghafouri-Fard S. Yari M, et al. Discov Oncol. 2025 Mar 8;16(1):282. doi: 10.1007/s12672-025-02026-z. Discov Oncol. 2025. PMID: 40056245 Free PMC article.
Regulation of immune-mediated chemoresistance in cancer by lncRNAs: an in-depth review of signaling pathways.
Jasim SA, Altalbawy FMA, Uthirapathy S, Bishoyi AK, Ballal S, Singh A, Devi A, Yumashev A, Mustafa YF, Abosaoda MK. Jasim SA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 9. doi: 10.1007/s00210-025-04081-3. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 40202675 Review.

See all "Cited by" articles

References

1. Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127(16):3029–30. https://doi.org/10.1002/cncr.33587 . - DOI - PubMed
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660 . - DOI - PubMed
1. Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, et al. Landscape of transcription in human cells. Nature. 2012;489(7414):101–8. https://doi.org/10.1038/nature11233 . - DOI - PubMed - PMC
1. Consortium EP. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489(7414):57–74. https://doi.org/10.1038/nature11247 . - DOI
1. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell. 2009;136(4):629–41. https://doi.org/10.1016/j.cell.2009.02.006 . - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

LncRNA CASC19: a novel oncogene involved in human cancer

Affiliations

LncRNA CASC19: a novel oncogene involved in human cancer

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical