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Review
. 2023 May;41(2):343-358.
doi: 10.1016/j.ncl.2023.01.001.

Sex Differences in Alzheimer's Disease

Neelum T Aggarwal  1 , Michelle M Mielke  2
Affiliations
Review

Sex Differences in Alzheimer's Disease

Neelum T Aggarwal et al. Neurol Clin. 2023 May.

Abstract

Reviewing the research presented in this article, it is evident that from an epidemiological perspective, it is important to evaluate the extent to which findings of sex and gender differences in Alzheimer's dementia (AD) are due to differences in longevity, survival bias, and comorbidities. Medical, genetic, psychosocial, and behavioral factors, in addition to hormonal factors, can differentially affect the risk and progression of AD in women versus men. Further, evaluation of sex differences in AD progression and the trajectory of change in cognitive function, neuroimaging, cerebrospinal fluid (CSF), and blood-based biomarkers of AD is needed. Finally, identifying sex differences in AD biomarkers and change across the lifespan is critical for the planning of prevention trials to reduce the risk of developing AD.

Keywords: Alzheimer’s dementia; Biomarkers; Cognitive decline; Risk factors; Sex differences.

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References

    1. Alzheimer’s Association, 2018 Alzheimer’s Disease Facts and Figures. Alzheimers Dement, 2018. 14(3): p. 367–429. - PubMed
    1. Petersen RC, et al., Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology, 2018. 90(3): p. 126–135. - PMC - PubMed
    1. Hebert LE, et al., Annual Incidence of Alzheimer Disease in the United States Projected to the Years 2000 Through 2050:. Alzheimer Disease and Associated Disorders, 2001. 15(4): p. 169–173. - PubMed
    1. Hebert LE, et al., Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology, 2013. 80(19): p. 1778–1783. - PMC - PubMed
    1. Chêne G, et al., Gender and incidence of dementia in the Framingham Heart Study from mid‐adult life. Alzheimer’s & Dementia, 2015. 11(3): p. 310–320. - PMC - PubMed

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