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Review
. 2023 Jun:162:114655.
doi: 10.1016/j.biopha.2023.114655. Epub 2023 Apr 7.

Biophysical cues to improve the immunomodulatory capacity of mesenchymal stem cells: The progress and mechanisms

Qingyuan Gao  1 , Fangru Jia  2 , Xiangpan Li  2 , Yanan Kong  2 , Zhenya Tian  2 , Lintao Bi  3 , Lisha Li  4
Affiliations
Free article
Review

Biophysical cues to improve the immunomodulatory capacity of mesenchymal stem cells: The progress and mechanisms

Qingyuan Gao et al. Biomed Pharmacother. 2023 Jun.
Free article

Abstract

Mesenchymal stem cells (MSCs) can maintain immune homeostasis and many preclinical trials with MSCs have been carried out around the world. In vitro culture of MSCs has been found to result in the decline of immunomodulatory capacity, migration and proliferation. To address these problems, simulating the extracellular environment for preconditioning of MSCs is a promising and inexpensive method. Biophysical cues in the external environment that MSCs are exposed to have been shown to affect MSC migration, residency, differentiation, secretion, etc. We review the main ways in which MSCs exert their immunomodulatory ability, and summarize recent advances in mechanical preconditioning of MSCs to enhance immunomodulatory capacity and related mechanical signal sensing and transduction mechanisms.

Keywords: Biophysical cue; Immunomodulation; Mechanism; Mechanotransduction; Mesenchymal stem cell; Preconditioning.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no conflict of interest and consent for publication. This study was funded by Science and Technology Department Project of Jilin Province (Grant no. 20230101163JC). The authors confirm independence from the sponsors; the content of the article has not been influenced by the sponsors.

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