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. 2023 Jun;64(6):1582-1593.
doi: 10.1111/epi.17613. Epub 2023 Apr 23.

Changes in local and network brain activity after stereotactic thermocoagulation in patients with drug-resistant epilepsy

Sara Simula  1 , Elodie Garnier  1 , Margherita Contento  2 , Francesca Pizzo  1   3   4 , Julia Makhalova  1   3   4 , Stanislas Lagarde  1   3   4 , Christian-George Bénar  1 , Fabrice Bartolomei  1   3   4
Affiliations

Changes in local and network brain activity after stereotactic thermocoagulation in patients with drug-resistant epilepsy

Sara Simula et al. Epilepsia. 2023 Jun.

Abstract

Objective: Stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) aims to reduce seizure frequency by modifying epileptogenic networks through local thermocoagulative lesions. Although RF-TC is hypothesized to functionally modify brain networks, reports of changes in functional connectivity (FC) following the procedure are missing. We evaluated, by means of SEEG recordings, whether variation in brain activity after RF-TC is related to clinical outcome.

Methods: Interictal SEEG recordings from 33 patients with drug-resistant epilepsy (DRE) were analyzed. Therapeutic response was defined as a >50% reduction in seizure frequency for at least 1 month following RF-TC. Local (power spectral density [PSD]) and FC changes were evaluated in 3-min segments recorded shortly before (baseline), shortly after, and 15 min after RF-TC. The PSD and FC strength values after thermocoagulation were compared with baseline as well as between the responder and nonresponder groups.

Results: In responders, we found a significant reduction in PSD after RF-TC in channels that were thermocoagulated for all frequency bands (p = .007 for broad, delta and theta, p <.001 for alpha and beta bands). However, we did not observe such PSD decrease in nonresponders. At the network level, nonresponders displayed a significant FC increase in all frequency bands except theta (broad, delta, beta band: p <.001; alpha band: p <.01), although responders showed a significant FC decrease in delta (p <.001) and alpha bands (p <.05). Nonresponders showed stronger FC changes with respect to responders exclusively in TC channels (broad, alpha, theta, beta: p >.05; delta: p = .001).

Significance: Thermocoagulation induces both local and network-related (FC) changes in electrical brain activity of patients with DRE lasting for at least 15 min. This study demonstrates that the observed short-term modifications in brain network and local activity significantly differ between responders and nonresponders and opens new perspectives for studying the longer-lasting FC changes after RF-TC.

Keywords: SEEG; brain lesion; brain stimulation; functional connectivity; intracranial signal analysis.

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References

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