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Review
. 2023 Jan-Mar;17(1):65-71.
doi: 10.4103/sja.sja_822_22. Epub 2023 Jan 2.

Buprenorphine for acute post-surgical pain: A systematic review and meta-analysis

Mohammed S Albaqami  1 , Adel A Alqarni  2 , Musab S Alabeesy  3 , Ayidh N Alotaibi  3 , Hazzaa A Alharbi  3 , Mishari M Alshammari  3 , Ahmed H Aldhfery  3
Affiliations
Review

Buprenorphine for acute post-surgical pain: A systematic review and meta-analysis

Mohammed S Albaqami et al. Saudi J Anaesth. 2023 Jan-Mar.

Abstract

Our study was designed to evaluate the efficacy of buprenorphine for the management of acute post-surgical pain reported in published studies in the years 2015-2022. Comprehensive research was performed by using online resources like PUBMED and the Wiley Library database to gather the relevant literature. Two authors were assigned to independently collect the information. Cochran's Q-test and I square statistic were used to determine the heterogeneity across the studies. Publication bias was estimated by using the Egger regression analysis and found to be significantly present once the P value <0.05. In this review, 15 studies were included. The pooled ratio of pain reduction after 12 hours of surgery was reported as 11.2% with 97% heterogeneity. Day one shows 5.9 reductions in pain with 98% heterogeneity. The 3% more pain was reduced on day 2. The day 3 pooled pain reduction score was observed as 1.9%. The overall pool prevalence of pain reduction was noted as 6.2% at different time duration with significant heterogeneity of 100%. Buprenorphine transdermal and sublingual both have significant pain relief scores. The analgesic drug consumption was reduced at the end of the follow-up duration.

Keywords: Acute pain; buprenorphine; post-surgical pain.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart on PRISMA guidelines
Figure 2
Figure 2
Wald test of pain score at the different time duration
Figure 3
Figure 3
Egger regression asymmetry funnel plot
See this image and copyright information in PMC

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