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. 2023 Apr 1:15:435-446.
doi: 10.2147/CLEP.S401862. eCollection 2023.

Prevalence of Statin Use and Predictors of Statin Initiation Among Patients with Alcohol-Related Cirrhosis - A Danish Nationwide Cohort Study

Marine Sølling Ramsing  1 , Frederik Kraglund  1 , Peter Jepsen  1
Affiliations

Prevalence of Statin Use and Predictors of Statin Initiation Among Patients with Alcohol-Related Cirrhosis - A Danish Nationwide Cohort Study

Marine Sølling Ramsing et al. Clin Epidemiol. .

Abstract

Purpose: Statins reportedly increase the survival of patients with cirrhosis due to alcohol-related liver disease (ALD cirrhosis), but this association might be confounded by socioeconomic status. We examined the prevalence of statin use and socioeconomic and demographic predictors of statin initiation and discontinuation among patients with ALD cirrhosis.

Patients and methods: Using Danish nationwide healthcare registries, we examined statin use among patients diagnosed with ALD cirrhosis in 1997-2018. We computed the prevalence of statin use and incidence of statin initiation and discontinuation, and we used multivariable Cox regression to identify predictors of statin initiation and discontinuation.

Results: We identified 28,260 patients with ALD cirrhosis in 1997-2018. During this period, the prevalence of statin use rose sharply, reaching 19.0% in late 2018. Among patients diagnosed with ALD cirrhosis after 2010, 16.9% were using statins when they were diagnosed with cirrhosis. Among the patients who did not use statins initially, those with lower educational attainment were more likely to begin taking them than those with higher attainment. Also, cohabiting patients were more likely to begin than patients who lived alone, and employed patients were more likely to begin compared to patients outside the labour force. Among current statin users, unemployment predicted statin discontinuation.

Conclusion: The use of statins has become increasingly prevalent among Danish patients with ALD cirrhosis, reaching 19.0% in 2018. Employment, cohabitation, and a short education predicted statin initiation after ALD cirrhosis diagnosis, and unemployment predicted statin discontinuation. Overall, statin use was not a marker of a high socioeconomic status.

Keywords: alcoholic; anticholesteremic agents; hydroxymethylglutaryl-CoA reductase inhibitors; liver cirrhosis; socioeconomic factors.

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Conflict of interest statement

Ms Marine Sølling Ramsing reports grants from Novo Nordisk Foundation, during the conduct of the study. Dr Peter Jepsen reports grants from Novo Nordisk Foundation, during the conduct of the study. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Distribution of statin non-users, statin continuators and statin initiators in the cohort. The group that initiated statin treatment was compared to statin naïve patients.
Figure 2
Figure 2
Prevalence of statin use among patients with ALD cirrhosis with respect to calendar year. (Blue) Overall statin users after diagnosis. (Red) Statin user after first ALD cirrhosis diagnosis, initiated treatment before diagnosis. (Green) Statin user after first ALD cirrhosis diagnosis, initiated treatment after first ALD cirrhosis diagnosis.
Figure 3
Figure 3
Prevalence of statin use among patients with ALD cirrhosis with respect to time since cirrhosis diagnosis. This analysis is restricted to patients diagnosed with ALD cirrhosis after 1 January 2010.
See this image and copyright information in PMC

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