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Review
. 2023 Mar 22:14:1039490.
doi: 10.3389/fendo.2023.1039490. eCollection 2023.

Cancer-related hypercalcemia and potential treatments

Elvina Almuradova  1 , Irfan Cicin  2
Affiliations
Review

Cancer-related hypercalcemia and potential treatments

Elvina Almuradova et al. Front Endocrinol (Lausanne). .

Abstract

Cancer-related hypercalcemia is a common finding typically seen in patients with advanced cancer and occurs in about 20 to 30 percent of cases. The most common cause of hypercalcemia in hospitalized patients is hypercalcemia due to malignancy.This clinical problem is seen in patients with both solid tumors and patients with hematologic malignancies. Hypercalcemia is associated with a poor prognosis in oncology patients. This pathologic condition can occur due to many different mechanisms but is usually caused by abnormal calcium use resulting from bone resorption, intestinal absorption, or renal excretion. Hypercalcemia may present with a wide range of symptoms ranging from gastrointestinal system symptoms to neurologic symptoms. Timely diagnosis and initiation of treatment by the physician significantly reduce the risk of complications. Treatment aims to decrease serum calcium by increasing calciuresis, decreasing bone resorption, and decreasing intestinal calcium absorption. The mainstays of treatment are IV hydration, bisphosphonates and calcitonin, denosumab, and in some patients, prednisone, and cinacalcet. Patients with underlying advanced kidney disease and refractory severe hypercalcemia should be evaluated for hemodialysis. Every physician dealing with oncology patients should know the fastest and most effective management of hypercalcemia. We aimed to contribute in this sense.

Keywords: cancer; hypercalcaemia; maligancy; therapy; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Calcium metabolism. PTH: parathyroid hormone. Green, decreasing effect on serum calcium level. Red: increasing effect on serum calcium level.
Figure 2
Figure 2
The reasons of malignant hypercalcemia.
See this image and copyright information in PMC

References

    1. Jick S, Li L, Gastanaga VM, Liede A. Prevalence of hypercalcemia of malignancy among cancer patients in the UK: analysis of the clinical practice research datalink database. Cancer Epidemiol (2015) 39(6):901–7. doi: 10.1016/j.canep.2015.10.012 - DOI - PubMed
    1. Burt ME, Brennan MF. Incidence of hypercalcemia and malignant neoplasm. Arch Surg (1980) 115:704–7. doi: 10.1001/archsurg.1980.01380060012004 - DOI - PubMed
    1. Endres DB. Investigation of hypercalcemia. Clin Biochem (2012) 45:954–63. doi: 10.1016/j.clinbiochem.2012.04.025 - DOI - PubMed
    1. Mirrakhimov AE. Hypercalcemia of malignancy: An update on pathogenesis and management. N Am J Med Sci (2015) 7(11):483–93. doi: 10.4103/1947-2714.170600 - DOI - PMC - PubMed
    1. Sternlicht H, Glezerman IG. Hypercalcemia of malignancy and new treatment options. Ther Clin Risk Manag (2015) 11:1779–88. doi: 10.2147/TCRM.S83681 - DOI - PMC - PubMed