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. 2023 Mar 28;16(3):100724.
doi: 10.1016/j.waojou.2022.100724. eCollection 2023 Mar.

Epidemiology of adult patients with atopic dermatitis in AWARE 1: A second international survey

Jorge Maspero  1 , Norma De Paula Motta Rubini  2 , Jianzhong Zhang  3 , Gloria Sanclemente  4 , Julio Roberto Amador  5 , Mahira Hamdy El Sayed  6 , Alson Chan Wai Ming  7 , Roni P Dodiuk-Gad  8 , Issam Hamadah  9 , Suganthi Thevarajah  10 , Catalina Rincón-Perez  11 , Elena Fedenko  12 , Yik Weng Yew  13 , Mark B Y Tang  14 , Chia-Yu Chu  15 , Kanokvalai Kulthanan  16 , Ozlem Su Kucuk  17 , Anwar Al-Hammadi  18 , Lysel Brignoli  19 , Angelina Tsankova  19 , Sarah El-Samad  20 , Jose Eduardo Neves  21 , Laurent Eckert  22
Affiliations

Epidemiology of adult patients with atopic dermatitis in AWARE 1: A second international survey

Jorge Maspero et al. World Allergy Organ J. .

Erratum in

Abstract

Background: There are gaps in our understanding of the epidemiology of atopic dermatitis (AD) in adults.

Objective: To evaluate the prevalence and severity of AD in adults from countries/regions within Asia, Eurasia, Latin America, Middle East, and Russia.

Methods: This international, web-based survey was performed in Argentina, Brazil, China, Colombia, Egypt, Hong Kong, Israel, Malaysia, Mexico, Russia, Kingdom of Saudi Arabia (KSA), Singapore, Taiwan, Thailand, Turkey, and United Arab Emirates. Questionnaires were sent to adult members of online respondent panels for determination of AD and assessment of severity. A diagnosis of AD required respondents to meet the modified United Kingdom (UK) Working Party criteria and to self-report they had a physician diagnosis of AD. Severity of AD was determined using Patient-Oriented Scoring of Atopic Dermatitis (PO-SCORAD), Patient-Oriented Eczema Measure (POEM), and Patient Global Assessment (PGA).

Results: Among respondents by country/region the prevalence of AD ranged from 3.4% in Israel to 33.7% in Thailand. The prevalence was generally higher in females versus males. Severity varied by scale, although regardless of scale the proportion of respondents with mild and moderate disease was higher than severe disease. PGA consistently resulted in the lowest proportion of severe AD (range 2.4% China - 10.8% Turkey) relative to PO-SCORAD (range 13.4% China - 41.6% KSA) and POEM (range 5.1% China - 16.6% Israel).

Conclusions: This survey highlights the importance of AD in adults, with high prevalence and high morbidity among respondents and emphasizes that AD is not just a disease of childhood-there is disease persistence and chronicity in adults.

Keywords: Atopic dermatitis; Epidemiology; PO-SCORAD; POEM; Prevalence; Severity.

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Figures

Fig. 1
Fig. 1
Survey flowchart. AD, atopic dermatitis; KSA, Kingdom of Saudi Arabia; UAE, United Arab Emirates; UKWP, United Kingdom Working Party.
Fig. 2
Fig. 2
Gender distribution of the final sample (A), age distribution of the final sample (B). KSA, Kingdom of Saudi Arabia; UAE, United Arab Emirates.
Fig. 3
Fig. 3
Prevalence of AD among adults (A), and specialists who diagnosed respondents' AD (B). In B respondents had both self-declared AD diagnosis by a physician and fulfilled the UK Working Party criteria. AD, atopic dermatitis; KSA, Kingdom of Saudi Arabia; UAE, United Arab Emirates; UK, United Kingdom.
Fig. 4
Fig. 4
Prevalence of AD across genders (A), by age group (B), by residential area (C). Asterisk indicates prevalence significantly higher between male and female (P < 0.05). AD, atopic dermatitis; KSA, Kingdom of Saudi Arabia; UAE, United Arab Emirates.
Fig. 5
Fig. 5
Among the patients with AD: main specialist managing AD (A), respondents currently receiving treatment (B), respondents that had at least one comorbidity (C), and specific comorbidities (D). AD, atopic dermatitis; KSA, Kingdom of Saudi Arabia; UAE, United Arab Emirates; UK, United Kingdom.
Fig. 5
Fig. 5
Among the patients with AD: main specialist managing AD (A), respondents currently receiving treatment (B), respondents that had at least one comorbidity (C), and specific comorbidities (D). AD, atopic dermatitis; KSA, Kingdom of Saudi Arabia; UAE, United Arab Emirates; UK, United Kingdom.
Fig. 6
Fig. 6
Severity distributions for PO-SCORAD, POEM and PGA for respondents with AD (A) and for respondents with AD receiving treatment (B). AD, atopic dermatitis; PGA, Patients Global Assessment; POEM, Patient-Oriented Eczema Measure; PO-SCORAD, Patient-Oriented Scoring of Atopic Dermatitis; KSA, Kingdom of Saudi Arabia; UAE, United Arab Emirates.
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