Nucleoporin 98 mislocalization is a common feature in primary tauopathies

Abstract

This scientific commentary refers to 'Altered localization of nucleoporin 98 in primary tauopathies' by Dickson et al. (https://doi.org/10.1093/braincomms/fcac334).

Figure 1

Schematic diagram of a healthy neuron (left side) versus a diseased neuron (right side) in primary tauopathies. In the healthy neuron, in the absence of phospho-tau, there is no mislocalization of Nup98. On the other hand, in the diseased neuron of primary tauopathies, there is the presence of phospho-tau and nuclear and cytoplasmic mislocalization of Nup98.