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. 2023 Mar 8:14:1112922.
doi: 10.3389/fimmu.2023.1112922. eCollection 2023.

In good times and in bad: How plasma cells resolve stress for a life-long union with the bone marrow

Carolin Ulbricht  1   2 , Yu Cao  1   2 , Raluca A Niesner  3   4 , Anja E Hauser  1   2
Affiliations

In good times and in bad: How plasma cells resolve stress for a life-long union with the bone marrow

Carolin Ulbricht et al. Front Immunol. .
No abstract available

Keywords: antibody production; autophagy; bone marrow; calcium; long-lived plasma cells (LLPC); metabolism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Graphic representation of two hypothetic metabolic states of PC within the BM, depending on niche composition. In this model, PC within their stromal cell niche (green mesenchymal stem cells) are low in cytoplasmic calcium (I, blue PC) in times of sufficient nutrient supply (purple hexagons), e.g. due to a dense vessel network (red branches) and only few other hematopoietic cells (grey), competing for nutrients. Calcium-low cells produce antibodies at high rates. Vice versa, in times of metabolic stress (II) through decreased nutrient supply due to hematopoietic nutrient sinks or vessel remodeling (5), antibody output is decreased.
See this image and copyright information in PMC

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