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. 2022 Jul 6;15(1):9513.
doi: 10.4081/dr.2022.9513. eCollection 2023 Mar 7.

A case of sweat-gland carcinoma with neuroendocrine differentiation

Affiliations

A case of sweat-gland carcinoma with neuroendocrine differentiation

Shigeru Koizumi et al. Dermatol Reports. .
No abstract available

Keywords: Carcinoid tumor; Lymphatic metastasis; Mucinous carcinoma; Neuroendocrine tumor.

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Conflict of interest statement

Conflict of interest: The paper is exempt from

Figures

Figure 1.
Figure 1.
A) a red mulberry-shaped nodule on the lower abdomen to the base of the penis (30 mm × 25 mm × 15 mm) with some red papules on the margin; B) a dermoscopic image of the penile nodule showing branched and/or partially reticular linear vessels in a pale red structureless area.
Figure 2.
Figure 2.
Figure 2. A) histopathological features of the primary tumor. The tumor nests show diffuse infiltration from the upper dermis to the subcutaneous tissue (hematoxylin-eosin, original magnification ×40); B) tumor nests of varying sizes are seen (hematoxylineosin, ×200); C) the tumor cells are small- to medium-sized with abundant and pale eosinophilic cytoplasm, round-to-oval nuclei, and a “salt-and-pepper” chromatin pattern. Few nuclear atypia and mitotic figures are observed (hematoxylin-eosin, ×400); D) a tumor mass floating in abundant mucus is observed in part of the tumor (<10%) (hematoxylin-eosin, ×200); E) tumor cells displayed a trabecular growth pattern with abundant extracellular mucin deposition in the resected lymph node (hematoxylineosin, ×200).

References

    1. Van Dijk C, Ten Seldam RE. A possible primary cutaneous carcinoid. Cancer 1975;36:1016-20. - PubMed
    1. Chen TY, Morrison AO, Susa J, Cockerell CJ. Primary low-grade neuroendocrine carcinoma of the skin: An exceedingly rare entity. J Cutan Pathol 2017;44:978-81. - PubMed
    1. Goto K, Anan T, Nakatsuka T, et al. Low-Grade Neuroendocrine Carcinoma of the Skin (Primary Cutaneous Carcinoid Tumor) as a Distinctive Entity of Cutaneous Neuroendocrine Tumors: A Clinicopathologic Study of 3 Cases With Literature Review. Am J Dermatopathol 2017;39:250-8 - PubMed
    1. Goto K, Kukita Y, Honma K, et al. Sweat-gland carcinoma with neuroendocrine differentiation (SCAND): a clinicopathologic study of 13 cases with genetic analysis. Mod Pathol 2022;35:33-43. - PubMed
    1. Kim BJ, Choi HJ, Kim HJ, et al. A Case of Primary Cutaneous Mucinous Carcinoma with Neuroendocrine Differentiation. Ann Dermatol 2010;22:472-7. - PMC - PubMed