Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 23:68:1605300.
doi: 10.3389/ijph.2023.1605300. eCollection 2023.

Temporal Trends in the Incidence and Mortality of Major Reproductive-Related Cancers in Women in Guangzhou From 2010 to 2020: A Joinpoint and Age-Period-Cohort Study

Suixiang Wang  1 , Shan Liu  2 , Zhiqiang Nie  3 , Yexin Li  2 , Ke Li  1 , Huanzhu Liang  2 , Qian Chen  2 , Lin Wen  2 , Huan Xu  1 , Boheng Liang  1 , Pengzhe Qin  1 , Chunxia Jing  2   4
Affiliations

Temporal Trends in the Incidence and Mortality of Major Reproductive-Related Cancers in Women in Guangzhou From 2010 to 2020: A Joinpoint and Age-Period-Cohort Study

Suixiang Wang et al. Int J Public Health. .

Abstract

Objective: To understand the temporal trends of cancer incidence and mortality in women in Guangzhou during the past 11 years and provide clues for future research. Methods: Data were obtained from the Guangzhou Cancer and Death Registry. Average annual percentage changes (AAPCs) in age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were obtained by joinpoint regression. The age-period-cohort (APC) model was generated to quantify the effects of age, period, and cohort. Results: The ASIRs for cervical (AAPC = -4.3%) and ovarian (AAPC = -3.2%) cancers showed a downward trend during 2010-2020, and that for uterine cancer showed an upward trend. The ASMRs of breast (APC = 5.0%) and cervical (APC = 8.8%) cancers increased. The APC model highlights different age, period, and birth cohort effects depending on the cancer site. Conclusion: The ASIRs for cervical and ovarian cancers among women in Guangzhou showed a decreasing trend during the period. The APC model showed mortality for 4 cancers increased with age. Incidence and mortality decreased with increasing birth cohort. Annual reproductive cancer screening is recommended for women of appropriate age to reduce the disease burden.

Keywords: Guangzhou; age-period-cohort analysis; joinpoint regression; reproductive-related cancers; women.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they do not have any conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Analysis of women reproductive-related cancers incidence by APC model. (A) Breast cancer, (B) Cervical cancer, (C) Uterine cancer, (D) Ovarian cancer. Guangzhou 2010–2020.
FIGURE 2
FIGURE 2
Analysis of women reproductive-related cancers mortality by APC model. (A) Breast cancer, (B) Cervical cancer, (C) Uterine cancer, (D) Ovarian cancer. Guangzhou 2010–2020.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA: a Cancer J clinicians (2021) 71(1):7–33. 10.3322/caac.21654 - DOI - PubMed
    1. Zeng Yuhuan XL, Xu Y, Tan J, Xu X, Yu Y, Lin Y. Analysis of Malignant Tumor Incidence and Mortality in Guangdong Tumor Registration Areas in 2014. South China Prev (2021) 47(05):623–6.
    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global Cancer Statistics. CA: a Cancer J clinicians (2015) 65(2):87–108. 10.3322/caac.21262 - DOI - PubMed
    1. Yearbook CS. Mortality Rates and Composition of Major Diseases in Cities. Beijing, China: Beijing Union Medical College Press; (2010).
    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a Cancer J clinicians (2021) 71(3):209–49. 10.3322/caac.21660 - DOI - PubMed