Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 22:13:1067353.
doi: 10.3389/fonc.2023.1067353. eCollection 2023.

Analysis of risk factors of hepatocellular carcinoma and establishment of a clinical prognosis model

Xin-Yu Ge  1 , Ming-Chen Sun  1 , Tian-Yi Wang  1 , Xi-Min Wang  2 , Gang Liu  2 , Tao Yang  1 , Yi-Ming Lu  2 , Wei Wang  1
Affiliations

Analysis of risk factors of hepatocellular carcinoma and establishment of a clinical prognosis model

Xin-Yu Ge et al. Front Oncol. .

Abstract

Liver cancer is a common malignancy of the digestive system. Hepatocellular carcinoma (HCC) accounts for the most majority of these tumors and it has brought a heavy medical burden to underdeveloped countries and regions. Many factors affect the prognosis of HCC patients, however, there is no specific statistical model to predict the survival time of clinical patients. This study derived a risk factor signature of HCC and reliable clinical prediction model by statistically analyzing The Surveillance, Epidemiology, and End Results (SEER) database patient information using an open source package in the python environment.

Keywords: HCC (hepatic cellular carcinoma); SEER (Surveillance Epidemiology and End Results) database; machine learning - ML; random survival forest model; risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Risk factors assessment for HCC patients..
Figure 2
Figure 2
Survival curves for the surgery and non-surgery groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Zhou JM, Wang T, Zhang KH. Afp-L3 for the diagnosis of early hepatocellular carcinoma: A meta-analysis. Med (Baltimore) (2021) 100(43):e27673. doi: 10.1097/MD.0000000000027673 - DOI - PMC - PubMed
    1. Liu M, Zhao Q, Zheng X, Yang L, Zhao Y, Li X, et al. . Transcriptome changes in Ergic3-knockdown hepatocellular carcinoma cells: Ergic3 is a novel immune function related gene. PeerJ (2022) 10:e13369. doi: 10.7717/peerj.13369 - DOI - PMC - PubMed
    1. Petrick JL, Braunlin M, Laversanne M, Valery PC, Bray F, McGlynn KA. International trends in liver cancer incidence, overall and by histologic subtype, 1978-2007. Int J Cancer (2016) 139(7):1534–45. doi: 10.1002/ijc.30211 - DOI - PMC - PubMed
    1. Abbate V, Marcantoni M, Giuliante F, Vecchio FM, Gatto I, Mele C, et al. . Heppar1-positive circulating microparticles are increased in subjects with hepatocellular carcinoma and predict early recurrence after liver resection. Int J Mol Sci (2017) 18(5). doi: 10.3390/ijms18051043 - DOI - PMC - PubMed
    1. Tang H, You T, Sun Z, Bai C. A comprehensive prognostic analysis of Pold1 in hepatocellular carcinoma. BMC Cancer (2022) 22(1):197. doi: 10.1186/s12885-022-09284-y - DOI - PMC - PubMed

LinkOut - more resources