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Review
. 2023 Mar 24:11:1123753.
doi: 10.3389/fcell.2023.1123753. eCollection 2023.

The dual role of autophagy in periprosthetic osteolysis

Zhaoyang Yin  1 , Ge Gong  2 , Xiang Wang  3 , Wei Liu  3 , Bin Wang  3 , Jian Yin  3
Affiliations
Review

The dual role of autophagy in periprosthetic osteolysis

Zhaoyang Yin et al. Front Cell Dev Biol. .

Abstract

Periprosthetic osteolysis (PPO) induced by wear particles is an important cause of aseptic loosening after artificial joint replacement, among which the imbalance of osteogenesis and osteoclastic processes occupies a central position. The cells involved in PPO mainly include osteoclasts (macrophages), osteoblasts, osteocytes, and fibroblasts. RANKL/RANK/OGP axis is a typical way for osteolysis. Autophagy, a mode of regulatory cell death and maintenance of cellular homeostasis, has a dual role in PPO. Although autophagy is activated in various periprosthetic cells and regulates the release of inflammatory cytokines, osteoclast activation, and osteoblast differentiation, its beneficial or detrimental role remains controversy. In particular, differences in the temporal control and intensity of autophagy may have different effects. This article focuses on the role of autophagy in PPO, and expects the regulation of autophagy to become a powerful target for clinical treatment of PPO.

Keywords: RANKL; aseptic loosening; autophagy; mitophagy; periprosthetic osteolysis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The process of autophagy.
FIGURE 2
FIGURE 2
Autophagy in the activation and maturation of osteoclasts.
See this image and copyright information in PMC

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