Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 22;14(2):12-20.
doi: 10.4291/wjgp.v14.i2.12.

Role of T-box transcription factor 3 in gastric cancers

Naoki Asano  1 , Akira Imatani  2 , Akio Takeuchi  2 , Masashi Saito  2 , Xiao-Yi Jin  2 , Waku Hatta  2 , Kaname Uno  2 , Tomoyuki Koike  2 , Atsushi Masamune  2
Affiliations
Review

Role of T-box transcription factor 3 in gastric cancers

Naoki Asano et al. World J Gastrointest Pathophysiol. .

Abstract

The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.

Keywords: Aging; Carcinogenesis; Stomach; Transforming growth factor-β; Wnt; β-catenin.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: Dr. Asano reports grants from Japan Society for the Promotion of Science, during the conduct of the study.

Figures

Figure 1
Figure 1
The role of T-box transcription factor 3 in cancers. A schema describing the regulation and function of T-box transcription factor 3 in cancers. P: Phosphorylation; EMT: Epithelial-mesenchymal transition; TGF-β: Transforming growth factor-β; TBX3: T-box transcription factor 3.
See this image and copyright information in PMC

References

    1. Naiche LA, Harrelson Z, Kelly RG, Papaioannou VE. T-box genes in vertebrate development. Annu Rev Genet. 2005;39:219–239. - PubMed
    1. Papaioannou VE. T-box genes in development: from hydra to humans. Int Rev Cytol. 2001;207:1–70. - PubMed
    1. Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Schinzel A, Seidman JG, Seidman CE, Jorde LB. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet. 1997;16:311–315. - PubMed
    1. Davenport TG, Jerome-Majewska LA, Papaioannou VE. Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development. 2003;130:2263–2273. - PubMed
    1. Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, 't Hoen PA, Kispert A, Christoffels VM. Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci. 2012;69:1377–1389. - PMC - PubMed