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Review
. 2023 Mar 22;14(2):12-20.
doi: 10.4291/wjgp.v14.i2.12.

Role of T-box transcription factor 3 in gastric cancers

Naoki Asano  1 , Akira Imatani  2 , Akio Takeuchi  2 , Masashi Saito  2 , Xiao-Yi Jin  2 , Waku Hatta  2 , Kaname Uno  2 , Tomoyuki Koike  2 , Atsushi Masamune  2
Affiliations
Review

Role of T-box transcription factor 3 in gastric cancers

Naoki Asano et al. World J Gastrointest Pathophysiol. .

Abstract

The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.

Keywords: Aging; Carcinogenesis; Stomach; Transforming growth factor-β; Wnt; β-catenin.

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Conflict of interest statement

Conflict-of-interest statement: Dr. Asano reports grants from Japan Society for the Promotion of Science, during the conduct of the study.

Figures

Figure 1
Figure 1
The role of T-box transcription factor 3 in cancers. A schema describing the regulation and function of T-box transcription factor 3 in cancers. P: Phosphorylation; EMT: Epithelial-mesenchymal transition; TGF-β: Transforming growth factor-β; TBX3: T-box transcription factor 3.
See this image and copyright information in PMC

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