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. 2023 Mar 22:10:1156254.
doi: 10.3389/fmed.2023.1156254. eCollection 2023.

Genetically predicted green tea intake and the risk of arterial embolism and thrombosis

Lingmei Jia  1 , Yali Chen  1 , Chang Liu  1 , Yinyin Luan  1 , Min Jia  1
Affiliations

Genetically predicted green tea intake and the risk of arterial embolism and thrombosis

Lingmei Jia et al. Front Med (Lausanne). .

Abstract

Background: In previous observational studies, green tea intake has been demonstrated to protect against arterial embolism and thrombosis. However, whether there is a causative connection between green tea intake and arterial embolism and thrombosis is currently unclear.

Methods: A two-sample Mendelian randomization (MR) study has been designed to explore whether there is a causal association between green tea intake and arterial embolism and thrombosis by acquiring exposure and outcome data from previously published research. Data from the MRC-IEU (data on green tea intake, 64,949 participants) consortium and the FinnGen project (data on arterial embolism and thrombosis, 278 cases of arterial thrombosis and 92,349 control participants) has been utilized to determine the causal impact of green tea intake on arterial embolism and thrombosis.

Results: We found that genetically predicted green tea intake was causally associated with a lower risk of arterial embolism and thrombosis (IVW odds ratio [OR] per SD decrease in green tea intake = 0.92 [95% confidence interval, 0.85-0.99]; p = 0.032). Moreover, the sensitivity analysis (both MR Egger regression and weighted median) yielded comparable estimates but with low precision. No directional pleiotropic effect between green tea intake and arterial embolism and thrombosis was observed in both funnel plots and MR-Egger intercepts.

Conclusions: Our study provided causal evidence that genetically predicted green tea intake may be a protective factor against arterial embolism and thrombosis.

Keywords: Mendelian randomization; arterial embolism and thrombosis; genome-wide association study; green tea intake; ischemic heart disease; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of our MR analysis.
Figure 2
Figure 2
Scatter plot to visualize the causal effect of hypertension on the risk of ED. The slope of the straight line shows the magnitude of the causal association. IVW indicates inverse-variance weighted; and MR, Mendelian randomization.
Figure 3
Figure 3
Forest plot to visualize the causal effect of every single SNP on ED. MR indicates Mendelian randomization.
Figure 4
Figure 4
Funnel plots to visualize the overall heterogeneity of MR estimates for the effect of hypertension on the risk of ED. IVW indicates inverse-variance weighted, and MR indicates Mendelian randomization.
Figure 5
Figure 5
Leave-one-out plot to visualize the causal effect of hypertension on the risk of ED when leaving one SNP out MR indicates Mendelian randomization.
See this image and copyright information in PMC

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