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. 2023 Mar 31;12(3):320-330.
doi: 10.21037/tp-22-310. Epub 2023 Mar 9.

C3dg and MAC complement depositions in the renal histopathology of patients with lupus nephropathy

Yu Shi #  1 , Yuanyan Jiang #  1 , Haimei Liu  1 , Guoming Li  1 , Wen Yao  1 , Tao Zhang  1 , Yifan Li  1 , Wanzhen Guan  1 , Li Sun  1 , Hong Xu  1
Affiliations

C3dg and MAC complement depositions in the renal histopathology of patients with lupus nephropathy

Yu Shi et al. Transl Pediatr. .

Abstract

Background: Childhood-onset systemic lupus erythematosus (SLE) refers to SLE with an onset before 18 years old. The key to the pathogenesis of SLE tissue inflammation and injury is complement activation. The presence of complement split C3dg and membrane attack complex (MAC) may indicate a worse prognosis for lupus nephritis (LN). This study investigated whether complement split C3dg and MAC depositions in the pathogenesis of LN are potential biomarkers of disease severity and tissue injury.

Methods: The data on patients with LN were retrospectively analyzed in our center between April 2018 and December 2020. The depositions of C3dg and MAC were detected by immunofluorescence staining.

Results: C3dg and MAC were both detected in specimens from 61.5% of patients. Patients with MAC depositions had a greater proportion of neurological disorders than those without MAC depositions (22.9% vs. 3.3%; P=0.044). We found significant differences in serum creatinine, urinary protein, and estimated glomerular filtration rate (eGFR) in all four groups of patients with differing degrees of C3dg and MAC depositions.

Conclusions: This study suggests that C3dg and MAC depositions may be potential biomarkers for disease severity and tissue injury in LN. MAC and C3dg staining may be useful in routine studies of lupus biopsies to identify patients who need more aggressive treatment.

Keywords: C3dg; Lupus nephritis (LN); complement split; membrane attack complex (MAC).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-22-310/coif). All authors report the support from the 2021 Pujiang Young Rheumatologists Cultivation Plan (No. SPROG2101). The authors have no other conflicts of interest to declare.

Figures

Figure 1
Figure 1
ROC curves and predictive value of C3dg and MAC deposition. ROC, receiver operating characteristic; MAC, membrane attack complex.
See this image and copyright information in PMC

References

    1. Yu F, Haas M, Glassock R, et al. Redefining lupus nephritis: clinical implications of pathophysiologic subtypes. Nat Rev Nephrol 2017;13:483-95. 10.1038/nrneph.2017.85 - DOI - PubMed
    1. Wenderfer SE, Eldin KW. Lupus Nephritis. Pediatr Clin North Am 2019;66:87-99. 10.1016/j.pcl.2018.08.007 - DOI - PubMed
    1. Merola JF, Bermas B, Lu B, et al. Clinical manifestations and survival among adults with (SLE) according to age at diagnosis. Lupus 2014;23:778-84. 10.1177/0961203314526291 - DOI - PMC - PubMed
    1. Ortega LM, Schultz DR, Lenz O, et al. Review: Lupus nephritis: pathologic features, epidemiology and a guide to therapeutic decisions. Lupus 2010;19:557-74. 10.1177/0961203309358187 - DOI - PubMed
    1. Weinstein A, Alexander RV, Zack DJ. A Review of Complement Activation in SLE. Curr Rheumatol Rep 2021;23:16. 10.1007/s11926-021-00984-1 - DOI - PMC - PubMed