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. 2023 Mar 30;10(4):ofad150.
doi: 10.1093/ofid/ofad150. eCollection 2023 Apr.

Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)

Alexandra Griessbach  1 , Frédérique Chammartin  1 , Irene A Abela  2   3 , Patrizia Amico  4 , Marcel P Stoeckle  5 , Anna L Eichenberger  6 , Barbara Hasse  3 , Dominique L Braun  2   3 , Macé M Schuurmans  7 , Thomas F Müller  8 , Michael Tamm  9 , Annette Audigé  2 , Nicolas J Mueller  3 , Andri Rauch  6 , Huldrych F Günthard  2   3 , Michael T Koller  4 , Alexandra Trkola  2 , Selina Epp  2 , Alain Amstutz  1 , Christof M Schönenberger  1 , Ala Taji Heravi  1 , Katharina Kusejko  2   3 , Heiner C Bucher  1 , Matthias Briel  1   10 , Benjamin Speich  1 ; Swiss HIV Cohort Study and the Swiss Transplant Cohort Study
Collaborators, Affiliations

Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)

Alexandra Griessbach et al. Open Forum Infect Dis. .

Abstract

Extension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%-98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%-100.0%]) in individuals with different levels of immunosuppression (difference, -2.8% [95% CI, -6.8% to 1.3%]).

Keywords: HIV; Organ transplant; SARS-CoV-2; Vaccine; randomized trial.

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Conflict of interest statement

Potential conflicts of interest. B. S. and M. B. received a research grant from Moderna for the conduct of this study. H. C. B. has received in the 36 months prior to the submission of this manuscript grants, support for traveling, consultancy fees and honorarium from Gilead, BMS, ViiV Healthcare, Roche, and Pfizer that were not related to this project. He served as the president of the Association contre le HIV et autres infections transmissibles until June 2022. In this function he has received support for the SHCS from ViiV Healthcare, Gilead, BMS, and MSD. I. A. A. has received honoraria from MSD, Sanofi, and travel grant from Gilead Sciences and is supported by a research grant from the Promedica Foundation (all not related to this study). A. T. received a consultant fee from Roche and has received unrestricted research funding from Gilead and Roche not related to this study. D. L. B. received honoraria for advisory boards from the companies Gilead, MSD, and ViiV outside of the study. H. F. G., outside of this study, reports grants from the Swiss National Science Foundation, National Institutes of Health (NIH), and the SHCS; unrestricted research grants from Gilead Sciences, Roche, and Yvonne Jacob Foundation; and personal fees from consulting or advisory boards or data and safety monitoring boards for Merck, Gilead Sciences, ViiV Healthcare, Mepha, and Sandoz. H. F. G.'s institution received money for participation in the following clinical COVID-19 studies: 540-7773/5774 (Gilead), TICO (ACTIV-3, INSIGHT/NIH), and the Morningsky study (Roche). N. J. M. received honoraria for advisory boards from the companies Pfizer and Takeda outside of the study. A. R. reports support to his institution for advisory boards and/or travel grants from MSD, Gilead Sciences, Pfizer, and Moderna, and an investigator-initiated trial grant from Gilead Sciences. All remuneration went to his home institution and not to A. R. personally, and all remuneration was provided outside the submitted work. All other authors report no potential conflicts.

References

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